Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896513955> ?p ?o ?g. }
- W2896513955 abstract "Abstract Clearance of invading microbes requires phagocytes of the innate immune system. However, successful pathogens have evolved sophisticated strategies to evade immune killing. The opportunistic human fungal pathogen Candida albicans is efficiently phagocytosed by macrophages, but causes inflammasome activation, host cytolysis, and escapes after hypha formation. Previous studies suggest that macrophage lysis by C . albicans results from early inflammasome-dependent cell death (pyroptosis), late damage due to glucose depletion and membrane piercing by growing hyphae. Here we show that Candidalysin, a cytolytic peptide toxin encoded by the hypha-associated gene ECE1 , is both a central trigger for NLRP3 inflammasome-dependent caspase-1 activation via potassium efflux and a key driver of inflammasome-independent cytolysis of macrophages and dendritic cells upon infection with C . albicans . This suggests that Candidalysin-induced cell damage is a third mechanism of C . albicans -mediated mononuclear phagocyte cell death in addition to damage caused by pyroptosis and the growth of glucose-consuming hyphae." @default.
- W2896513955 created "2018-10-26" @default.
- W2896513955 creator A5002028663 @default.
- W2896513955 creator A5011368040 @default.
- W2896513955 creator A5013338602 @default.
- W2896513955 creator A5015341755 @default.
- W2896513955 creator A5026106737 @default.
- W2896513955 creator A5048439928 @default.
- W2896513955 creator A5052041258 @default.
- W2896513955 creator A5070624031 @default.
- W2896513955 creator A5082240161 @default.
- W2896513955 creator A5082720864 @default.
- W2896513955 creator A5085118360 @default.
- W2896513955 date "2018-10-15" @default.
- W2896513955 modified "2023-10-17" @default.
- W2896513955 title "The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes" @default.
- W2896513955 cites W1515994079 @default.
- W2896513955 cites W1529674879 @default.
- W2896513955 cites W1541195059 @default.
- W2896513955 cites W1605844554 @default.
- W2896513955 cites W1625775686 @default.
- W2896513955 cites W1861790843 @default.
- W2896513955 cites W1885912605 @default.
- W2896513955 cites W1891826181 @default.
- W2896513955 cites W1904683780 @default.
- W2896513955 cites W1964977785 @default.
- W2896513955 cites W1966625479 @default.
- W2896513955 cites W1971915082 @default.
- W2896513955 cites W1972724111 @default.
- W2896513955 cites W1980748692 @default.
- W2896513955 cites W1985970823 @default.
- W2896513955 cites W1988940275 @default.
- W2896513955 cites W1990172999 @default.
- W2896513955 cites W1991488616 @default.
- W2896513955 cites W1993727333 @default.
- W2896513955 cites W1993884627 @default.
- W2896513955 cites W1999340863 @default.
- W2896513955 cites W2001153857 @default.
- W2896513955 cites W2003064761 @default.
- W2896513955 cites W2004591077 @default.
- W2896513955 cites W2009800174 @default.
- W2896513955 cites W2018782288 @default.
- W2896513955 cites W2022323546 @default.
- W2896513955 cites W2025355874 @default.
- W2896513955 cites W2029949690 @default.
- W2896513955 cites W2031701891 @default.
- W2896513955 cites W2043931994 @default.
- W2896513955 cites W2047521705 @default.
- W2896513955 cites W2048844594 @default.
- W2896513955 cites W2050844765 @default.
- W2896513955 cites W2051444314 @default.
- W2896513955 cites W2060721894 @default.
- W2896513955 cites W2075428144 @default.
- W2896513955 cites W2075611712 @default.
- W2896513955 cites W2079185366 @default.
- W2896513955 cites W2079882002 @default.
- W2896513955 cites W2081158387 @default.
- W2896513955 cites W2088254488 @default.
- W2896513955 cites W2090859543 @default.
- W2896513955 cites W2096037926 @default.
- W2896513955 cites W2097714951 @default.
- W2896513955 cites W2099540110 @default.
- W2896513955 cites W2102019227 @default.
- W2896513955 cites W2107794472 @default.
- W2896513955 cites W2117231363 @default.
- W2896513955 cites W2119507799 @default.
- W2896513955 cites W2123087870 @default.
- W2896513955 cites W2126384811 @default.
- W2896513955 cites W2130941282 @default.
- W2896513955 cites W2140804868 @default.
- W2896513955 cites W2141563676 @default.
- W2896513955 cites W2142140971 @default.
- W2896513955 cites W2148931210 @default.
- W2896513955 cites W2155990940 @default.
- W2896513955 cites W2158528341 @default.
- W2896513955 cites W2170064977 @default.
- W2896513955 cites W2171564050 @default.
- W2896513955 cites W2220848304 @default.
- W2896513955 cites W2261682386 @default.
- W2896513955 cites W2329943654 @default.
- W2896513955 cites W2398372682 @default.
- W2896513955 cites W2473262875 @default.
- W2896513955 cites W2537020507 @default.
- W2896513955 cites W2550262882 @default.
- W2896513955 cites W2572113648 @default.
- W2896513955 cites W2573995712 @default.
- W2896513955 cites W2766780160 @default.
- W2896513955 cites W2767659580 @default.
- W2896513955 cites W2775367483 @default.
- W2896513955 cites W2784576924 @default.
- W2896513955 cites W2791421665 @default.
- W2896513955 cites W2800526695 @default.
- W2896513955 cites W2806470471 @default.
- W2896513955 cites W2888403349 @default.
- W2896513955 doi "https://doi.org/10.1038/s41467-018-06607-1" @default.
- W2896513955 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6189146" @default.
- W2896513955 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323213" @default.
- W2896513955 hasPublicationYear "2018" @default.
- W2896513955 type Work @default.
- W2896513955 sameAs 2896513955 @default.