FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896514092> ?p ?o ?g. }

• W2896514092 endingPage "212" @default.
• W2896514092 startingPage "205" @default.
• W2896514092 abstract "The interaction between antibodies and Immune cells surface FcγRIIIa (CD16a) receptor triggers a variety of immune responses including antibody-dependent cell-mediated cytotoxicity, antibody neutralization, phagocytosis, inflammation and tissue injury. Recent studies showed that IgG1 upper hinge region and FcγRs polymorphism play a major role in the interaction with Fcγ receptors and in the stability of the immune complex hence, in mounting strong inflammatory response. To further investigate this issue, we developed a tool box of IgG1 Fc isoforms to depict the affinity between mutated IgG1 Fc regions and extracellular domain variants (V158F) of CD16a. Our strategy consisted of designing different random upper-hinge mutated variants of IgG1 Fc domain, reproducing the naturally occurring two variants of CD16a and producing all of them as recombinant fusion proteins in Pichia Pastoris. The interactions were assayed using the Surface Plasmon Resonance (Biacore) method along with an in silico analysis to identify the major interaction and key residues that underline the affinity between the Fc region and CD16a variants. Our data showed that the affinity of the Fc region to the CD16a is strongly correlated to polar interactions. This molecular engineering approach yielded an IgG1Fc mutant with enhanced binding affinity to CD16a F158 variant." @default.
• W2896514092 created "2018-10-26" @default.
• W2896514092 creator A5000650483 @default.
• W2896514092 creator A5001245904 @default.
• W2896514092 creator A5024041797 @default.
• W2896514092 creator A5030385185 @default.
• W2896514092 creator A5042031340 @default.
• W2896514092 date "2018-06-01" @default.
• W2896514092 modified "2023-10-10" @default.
• W2896514092 title "Engineering of the upper hinge region of human IgG1 Fc enhances the binding affinity to FcγIIIa (CD16a) receptor isoform" @default.
• W2896514092 cites W1562483237 @default.
• W2896514092 cites W1563403908 @default.
• W2896514092 cites W1580407891 @default.
• W2896514092 cites W1965962344 @default.
• W2896514092 cites W1966122087 @default.
• W2896514092 cites W1989794537 @default.
• W2896514092 cites W2027025153 @default.
• W2896514092 cites W2047807371 @default.
• W2896514092 cites W2056576838 @default.
• W2896514092 cites W2080836516 @default.
• W2896514092 cites W2081362512 @default.
• W2896514092 cites W2106114908 @default.
• W2896514092 cites W2110286249 @default.
• W2896514092 cites W2110585060 @default.
• W2896514092 cites W2122584026 @default.
• W2896514092 cites W2138270253 @default.
• W2896514092 cites W2143867423 @default.
• W2896514092 cites W2152702121 @default.
• W2896514092 cites W2155747723 @default.
• W2896514092 cites W2168313542 @default.
• W2896514092 cites W2182452189 @default.
• W2896514092 cites W2256769101 @default.
• W2896514092 cites W2284926981 @default.
• W2896514092 cites W2368782122 @default.
• W2896514092 cites W2465121668 @default.
• W2896514092 cites W2534261386 @default.
• W2896514092 cites W2581539849 @default.
• W2896514092 cites W2592100001 @default.
• W2896514092 cites W2915163461 @default.
• W2896514092 cites W2915870000 @default.
• W2896514092 cites W2916340711 @default.
• W2896514092 cites W2973822473 @default.
• W2896514092 cites W4248961155 @default.
• W2896514092 doi "https://doi.org/10.1093/protein/gzy019" @default.
• W2896514092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30299461" @default.
• W2896514092 hasPublicationYear "2018" @default.
• W2896514092 type Work @default.
• W2896514092 sameAs 2896514092 @default.
• W2896514092 citedByCount "7" @default.
• W2896514092 countsByYear W28965140922019 @default.
• W2896514092 countsByYear W28965140922020 @default.
• W2896514092 countsByYear W28965140922022 @default.
• W2896514092 countsByYear W28965140922023 @default.
• W2896514092 crossrefType "journal-article" @default.
• W2896514092 hasAuthorship W2896514092A5000650483 @default.
• W2896514092 hasAuthorship W2896514092A5001245904 @default.
• W2896514092 hasAuthorship W2896514092A5024041797 @default.
• W2896514092 hasAuthorship W2896514092A5030385185 @default.
• W2896514092 hasAuthorship W2896514092A5042031340 @default.
• W2896514092 hasBestOaLocation W28965140921 @default.
• W2896514092 hasConcept C104317684 @default.
• W2896514092 hasConcept C125823703 @default.
• W2896514092 hasConcept C149774189 @default.
• W2896514092 hasConcept C153911025 @default.
• W2896514092 hasConcept C159654299 @default.
• W2896514092 hasConcept C170493617 @default.
• W2896514092 hasConcept C185592680 @default.
• W2896514092 hasConcept C203014093 @default.
• W2896514092 hasConcept C2779931124 @default.
• W2896514092 hasConcept C2780898057 @default.
• W2896514092 hasConcept C2781372317 @default.
• W2896514092 hasConcept C2909900342 @default.
• W2896514092 hasConcept C40767141 @default.
• W2896514092 hasConcept C55493867 @default.
• W2896514092 hasConcept C86803240 @default.
• W2896514092 hasConcept C95444343 @default.
• W2896514092 hasConceptScore W2896514092C104317684 @default.
• W2896514092 hasConceptScore W2896514092C125823703 @default.
• W2896514092 hasConceptScore W2896514092C149774189 @default.
• W2896514092 hasConceptScore W2896514092C153911025 @default.
• W2896514092 hasConceptScore W2896514092C159654299 @default.
• W2896514092 hasConceptScore W2896514092C170493617 @default.
• W2896514092 hasConceptScore W2896514092C185592680 @default.
• W2896514092 hasConceptScore W2896514092C203014093 @default.
• W2896514092 hasConceptScore W2896514092C2779931124 @default.
• W2896514092 hasConceptScore W2896514092C2780898057 @default.
• W2896514092 hasConceptScore W2896514092C2781372317 @default.
• W2896514092 hasConceptScore W2896514092C2909900342 @default.
• W2896514092 hasConceptScore W2896514092C40767141 @default.
• W2896514092 hasConceptScore W2896514092C55493867 @default.
• W2896514092 hasConceptScore W2896514092C86803240 @default.
• W2896514092 hasConceptScore W2896514092C95444343 @default.
• W2896514092 hasIssue "6" @default.
• W2896514092 hasLocation W28965140921 @default.
• W2896514092 hasLocation W28965140922 @default.
• W2896514092 hasOpenAccess W2896514092 @default.
• W2896514092 hasPrimaryLocation W28965140921 @default.
• W2896514092 hasRelatedWork W1825768998 @default.

• next