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• W2896514449 abstract "Regulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development of the hematopoietic system, for sustaining cell survival during generation of various cell types, in eliminating cells with dual identities such as CD4/CD8 double-positive cells (Hettmann, Didonato, Karin, & Leiden, 1999; Ogasawara, Suda, & Nagata, 1995), for sustaining cells during the rapid clonal expansion phase (Schirmer, Vallejo, Weyand, & Gronzy, 1998), as well as eliminating cells during the contraction phase (Yajima et al., 2006). The anti-apoptotic protein Mcl-1 is necessary for sustaining hematopoietic stem cells (HPS) (Akashi et al., 2003; Akashi, Traver, Miyamoto, & Weissman, 2000). The anti-apoptotic factors Mcl-1, Bcl-2, and Bcl-xL were also found to be over-expressed in acute myeloid leukemia (AML) (Kaufmann et al., 2016) and acute lymphocytic leukemia (ALL) (Findley, Gu, Yeager, & Zhou, 1997), suggesting that dis-regulated apoptotic processes could be a factor in the instigation of leukemia and/or its relapse. Molecules targeting these proteins were used as single agents to treat leukemia. However, by using a set of recently developed specific molecule inhibitors targeting anti-apoptotic proteins, distinct roles are being discovered for these anti-apoptotic proteins during hematopoietic and tumor development. Furthermore, using these inhibitors in proper combinations can effectively induce apoptosis in various solid tumors, even though each agent on its own cannot induce apoptosis in them. These new findings suggest that inhibiting anti-apoptotic elements can induce apoptosis without external stimuli in most cells, but it comes with a risk that some combinations could also trigger apoptosis in healthy cells. One way to address the safety issue is by limiting exposure to all the agents to only cancer cells, thus making the combination safe and effective. In this article, we review this rapidly developing idea in cancer research." @default.
• W2896514449 created "2018-10-26" @default.
• W2896514449 creator A5010282104 @default.
• W2896514449 creator A5032094772 @default.
• W2896514449 creator A5033306591 @default.
• W2896514449 date "2019-03-01" @default.
• W2896514449 modified "2023-10-03" @default.
• W2896514449 title "Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy" @default.
• W2896514449 cites W1584891848 @default.
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• W2896514449 cites W182803491 @default.
• W2896514449 cites W1969232124 @default.
• W2896514449 cites W1979248048 @default.
• W2896514449 cites W1981053512 @default.
• W2896514449 cites W1984547206 @default.
• W2896514449 cites W1987669002 @default.
• W2896514449 cites W1995773059 @default.
• W2896514449 cites W2001159673 @default.
• W2896514449 cites W2008845432 @default.
• W2896514449 cites W2010336934 @default.
• W2896514449 cites W2011614492 @default.
• W2896514449 cites W2013842624 @default.
• W2896514449 cites W2017457433 @default.
• W2896514449 cites W2018618888 @default.
• W2896514449 cites W2024011783 @default.
• W2896514449 cites W2028526641 @default.
• W2896514449 cites W2032769297 @default.
• W2896514449 cites W2048284951 @default.
• W2896514449 cites W2050093720 @default.
• W2896514449 cites W2055194057 @default.
• W2896514449 cites W2057303404 @default.
• W2896514449 cites W2059340786 @default.
• W2896514449 cites W2059958613 @default.
• W2896514449 cites W2062133747 @default.
• W2896514449 cites W2062807784 @default.
• W2896514449 cites W2064937772 @default.
• W2896514449 cites W2066404900 @default.
• W2896514449 cites W2069326426 @default.
• W2896514449 cites W2069509416 @default.
• W2896514449 cites W2076417705 @default.
• W2896514449 cites W2090287336 @default.
• W2896514449 cites W2090786449 @default.
• W2896514449 cites W2094061401 @default.
• W2896514449 cites W2103490418 @default.
• W2896514449 cites W2104412320 @default.
• W2896514449 cites W2105042816 @default.
• W2896514449 cites W2109224231 @default.
• W2896514449 cites W2110925122 @default.
• W2896514449 cites W2112604847 @default.
• W2896514449 cites W2113767619 @default.
• W2896514449 cites W2119316461 @default.
• W2896514449 cites W2121348722 @default.
• W2896514449 cites W2127376103 @default.
• W2896514449 cites W2130629430 @default.
• W2896514449 cites W2135487116 @default.
• W2896514449 cites W2136910701 @default.
• W2896514449 cites W2137240394 @default.
• W2896514449 cites W2139347878 @default.
• W2896514449 cites W2139594142 @default.
• W2896514449 cites W2142977207 @default.
• W2896514449 cites W2144450295 @default.
• W2896514449 cites W2151960655 @default.
• W2896514449 cites W2152876030 @default.
• W2896514449 cites W2157965986 @default.
• W2896514449 cites W2161545183 @default.
• W2896514449 cites W2163717251 @default.
• W2896514449 cites W2166467949 @default.
• W2896514449 cites W2168632005 @default.
• W2896514449 cites W2177641847 @default.
• W2896514449 cites W2291176625 @default.
• W2896514449 cites W2303309927 @default.
• W2896514449 cites W2416288303 @default.
• W2896514449 cites W2534349779 @default.
• W2896514449 cites W2566496356 @default.
• W2896514449 cites W2624273786 @default.
• W2896514449 cites W2743418290 @default.
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• W2896514449 cites W2889850618 @default.
• W2896514449 cites W2891173371 @default.
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• W2896514449 doi "https://doi.org/10.1016/j.pharmthera.2018.10.009" @default.
• W2896514449 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347215" @default.
• W2896514449 hasPublicationYear "2019" @default.
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