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• W2896514648 abstract "New pyrrolidine alkaloids, preussins C-I (1-7) and (11 R)/(11 S)-preussins J and K (8 and 9), were isolated from the sponge-derived fungus Aspergillus flocculosus 16D-1. The structures and configurations of these preussins were elucidated by detailed spectroscopic analysis, modified Mosher's method, and comparisons with literature data. These compounds showed strong to moderate inhibitory activity toward IL-6 production in lipopolysaccharide-induced THP-1 cells with IC50 values ranging from 0.11 to 22 μM, but were inactive against normal tumor cell lines and fungi." @default.
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• W2896514648 date "2018-10-15" @default.
• W2896514648 modified "2023-10-18" @default.
• W2896514648 title "Preussins with Inhibition of IL-6 Expression from <i>Aspergillus flocculosus</i> 16D-1, a Fungus Isolated from the Marine Sponge <i>Phakellia fusca</i>" @default.
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• W2896514648 doi "https://doi.org/10.1021/acs.jnatprod.8b00662" @default.
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