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- W2896518198 endingPage "938" @default.
- W2896518198 startingPage "925" @default.
- W2896518198 abstract "Acute brain injuries represent major causes of morbidity and mortality worldwide. Nevertheless, therapeutic options are centered mainly on supportive care, and accurate prognosis prediction following traumatic brain injury (TBI) or stroke remains a challenge in clinical settings. Areas covered: Circulating DNA and RNA have shown potential as predictive molecules in acute brain injuries. In particular, plasma cell-free DNA (cfDNA) levels have been correlated to severity, mortality, and outcome after TBI and stroke. The real-time quantitative polymerase chain reaction (qPCR) is the most widely used technique for determination of cfDNA in brain injuries; however, to consider the use of cfDNA in emergency settings, a quicker and easier methodology for detection should be established. A recent study proposed detection of cfDNA applying a rapid fluorescent test that showed compatible results with qPCR. Expert commentary: As a promising perspective, detection of cfDNA levels using simple, rapid, and cheap methodology has potential to translate to clinic as a point-of-care marker, supporting the clinical decision-making in emergency care settings. Conversely, miRNA profiles may be used as signatures to determine the type and severity of injuries. Additionally, in the future, some miRNAs may constitute innovative neurorestorative therapies without the common hurdles associated with cell therapy." @default.
- W2896518198 created "2018-10-26" @default.
- W2896518198 creator A5017385038 @default.
- W2896518198 creator A5027095191 @default.
- W2896518198 creator A5038651514 @default.
- W2896518198 creator A5078909774 @default.
- W2896518198 creator A5086409359 @default.
- W2896518198 date "2018-10-22" @default.
- W2896518198 modified "2023-09-23" @default.
- W2896518198 title "Prognostic utility of circulating nucleic acids in acute brain injuries" @default.
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