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- W2896518535 abstract "The purpose of the study is to determine if statin use in clinically and autopsy confirmed AD is associated with a lower pathological burden (plaques, tangles, Braak). The hypothesis leading this investigation maintains that statin use should be associated with less AD pathology at autopsy. Throughout the field, there has been a debate on the efficacy of lipoproteins, specifically statins, in slowing the rate of decline in AD patients. The previous paper our team published showed that patients who used statins showed no negative effects of statins on AD decline. Further, it was found that AD patients on statins demonstrated a slight positive trend in cognitive decline, decreasing its rate1. We queried the National Alzheimer's Coordinating Center (NACC) database for autopsy-confirmed AD cases. Of the Uniform Data Set (UDS) participants who are deceased, 16,163 were diagnosed with dementia at their last UDS visit prior to death, and autopsy data is available for 3,945 patients. NACC data was available for 1,816 subjects that had clinically and pathologically confirmed AD. 1,558 were not on statins and 258 were on statins. There were no significant differences in age at death, age at onset, Braak stages, mean total tau, and mean total amyloid. Statin use in pathologically confirmed AD dementia does not appear to influence the amount of burden of plaques, tangles or Braak stage. Reference: 1. Smith KB, Kang P, Sabbagh MN, Alzheimer's Disease Neuroimaging Initiative. The effect of statins on rate of cognitive decline in mild cognitive impairment. Alzheimer's & Dementia : Translational Research & Clinical Interventions. 2017;3(2):149-156. https://doi.org/10.1016/j.trci.2017.01.001." @default.
- W2896518535 created "2018-10-26" @default.
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- W2896518535 date "2018-07-01" @default.
- W2896518535 modified "2023-09-26" @default.
- W2896518535 title "P3‐008: DOES TAKING STATINS AFFECT THE PATHOLOGICAL BURDEN IN AUTOPSY‐CONFIRMED ALZHEIMER'S DEMENTIA?" @default.
- W2896518535 doi "https://doi.org/10.1016/j.jalz.2018.06.1363" @default.
- W2896518535 hasPublicationYear "2018" @default.
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