FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896520301> ?p ?o ?g. }

• W2896520301 endingPage "2170" @default.
• W2896520301 startingPage "2159" @default.
• W2896520301 abstract "Despite the administration of exogenous insulin and other medications used to control many aspects of diabetes mellitus (DM), increased oxidative stress has been increasingly acknowledged in DM development and complications. Therefore, this study aims to investigate the role of advanced glycation end-products (AGEs) in oxidative stress (OS) of thyroid cells in patients with DM. Patients with DM with or without thyroid dysfunction (TD) were enrolled. Thyroid toxic damage was induced by adding AGE-modified bovine serum albumin (AGE-BSA) to normal human thyroid follicular epithelial cells. The cell viability, cell cycle, and cell apoptosis, as well as the content of reactive oxygen species (ROS), catalase (CAT), and malondialdehyde (MDA) in cells were measured. Thyroid hormones, T3, T4, FT3, and FT4 levels were measured by enzyme-linked immunosorbent assay. Receptor for advanced glycation end products (RAGE), sirtuin1 ( Sirt1), and NF-E2-related factor 2 ( Nrf2) expressions were detected, and the mitochondrial membrane potential was measured. We found increased AGEs in the serum of DM patients with TD. By increasing AGE-BSA concentration, cell viability; the thyroid hormones T3, T4, FT3, and FT4 levels; and mitochondrial membrane potential all significantly decreased. However, the increase in AGE-BSA concentration led to an increase in cell apoptosis, RAGE, and nuclear factor-κB expressions but produced the opposite effect on Sirt1, Nrf2, and heme oxygenase-1 expressions, as well as a decrease in antioxidant response element protein levels. The AGE-BSA increased ROS and MDA levels and reduced CAT level in normal human thyroid follicular epithelial cells on a dose independence basis. Our results demonstrated that AGEs-mediated direct increase of RAGE produced OS in thyroid cells of DM by inactivating the Sirt1/Nrf2 axis." @default.
• W2896520301 created "2018-10-26" @default.
• W2896520301 creator A5002661071 @default.
• W2896520301 creator A5007313208 @default.
• W2896520301 creator A5032148962 @default.
• W2896520301 creator A5047856716 @default.
• W2896520301 creator A5064640873 @default.
• W2896520301 creator A5070517216 @default.
• W2896520301 creator A5071537202 @default.
• W2896520301 date "2018-10-15" @default.
• W2896520301 modified "2023-10-16" @default.
• W2896520301 title "<i>Retracted</i> : Advanced glycation end‐products induce oxidative stress through the Sirt1/Nrf2 axis by interacting with the receptor of AGEs under diabetic conditions" @default.
• W2896520301 cites W1609670051 @default.
• W2896520301 cites W1965431364 @default.
• W2896520301 cites W1973722411 @default.
• W2896520301 cites W1974291218 @default.
• W2896520301 cites W1975759155 @default.
• W2896520301 cites W1981606978 @default.
• W2896520301 cites W1994051814 @default.
• W2896520301 cites W2003984928 @default.
• W2896520301 cites W2013532371 @default.
• W2896520301 cites W2015392958 @default.
• W2896520301 cites W2021988350 @default.
• W2896520301 cites W2034943656 @default.
• W2896520301 cites W2042130085 @default.
• W2896520301 cites W2044437167 @default.
• W2896520301 cites W2056469182 @default.
• W2896520301 cites W2057439688 @default.
• W2896520301 cites W2058900323 @default.
• W2896520301 cites W2061906058 @default.
• W2896520301 cites W2083040958 @default.
• W2896520301 cites W2084536221 @default.
• W2896520301 cites W2089097264 @default.
• W2896520301 cites W2109334664 @default.
• W2896520301 cites W2112132580 @default.
• W2896520301 cites W2113286227 @default.
• W2896520301 cites W2115408859 @default.
• W2896520301 cites W2121509432 @default.
• W2896520301 cites W2126730446 @default.
• W2896520301 cites W2129902595 @default.
• W2896520301 cites W2132203967 @default.
• W2896520301 cites W2134445381 @default.
• W2896520301 cites W2134628308 @default.
• W2896520301 cites W2167543749 @default.
• W2896520301 cites W2225072053 @default.
• W2896520301 cites W2294777723 @default.
• W2896520301 cites W2563035599 @default.
• W2896520301 cites W2737720674 @default.
• W2896520301 doi "https://doi.org/10.1002/jcb.27524" @default.
• W2896520301 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30324763" @default.
• W2896520301 hasPublicationYear "2018" @default.
• W2896520301 type Work @default.
• W2896520301 sameAs 2896520301 @default.
• W2896520301 citedByCount "20" @default.
• W2896520301 countsByYear W28965203012019 @default.
• W2896520301 countsByYear W28965203012020 @default.
• W2896520301 countsByYear W28965203012021 @default.
• W2896520301 countsByYear W28965203012022 @default.
• W2896520301 countsByYear W28965203012023 @default.
• W2896520301 crossrefType "journal-article" @default.
• W2896520301 hasAuthorship W2896520301A5002661071 @default.
• W2896520301 hasAuthorship W2896520301A5007313208 @default.
• W2896520301 hasAuthorship W2896520301A5032148962 @default.
• W2896520301 hasAuthorship W2896520301A5047856716 @default.
• W2896520301 hasAuthorship W2896520301A5064640873 @default.
• W2896520301 hasAuthorship W2896520301A5070517216 @default.
• W2896520301 hasAuthorship W2896520301A5071537202 @default.
• W2896520301 hasBestOaLocation W28965203011 @default.
• W2896520301 hasConcept C126322002 @default.
• W2896520301 hasConcept C134018914 @default.
• W2896520301 hasConcept C147990577 @default.
• W2896520301 hasConcept C169760540 @default.
• W2896520301 hasConcept C185592680 @default.
• W2896520301 hasConcept C190283241 @default.
• W2896520301 hasConcept C2775838275 @default.
• W2896520301 hasConcept C2776151105 @default.
• W2896520301 hasConcept C2778401633 @default.
• W2896520301 hasConcept C2778857457 @default.
• W2896520301 hasConcept C2778979269 @default.
• W2896520301 hasConcept C48349386 @default.
• W2896520301 hasConcept C526584372 @default.
• W2896520301 hasConcept C53227056 @default.
• W2896520301 hasConcept C55493867 @default.
• W2896520301 hasConcept C555293320 @default.
• W2896520301 hasConcept C71315377 @default.
• W2896520301 hasConcept C71924100 @default.
• W2896520301 hasConcept C86803240 @default.
• W2896520301 hasConceptScore W2896520301C126322002 @default.
• W2896520301 hasConceptScore W2896520301C134018914 @default.
• W2896520301 hasConceptScore W2896520301C147990577 @default.
• W2896520301 hasConceptScore W2896520301C169760540 @default.
• W2896520301 hasConceptScore W2896520301C185592680 @default.
• W2896520301 hasConceptScore W2896520301C190283241 @default.
• W2896520301 hasConceptScore W2896520301C2775838275 @default.
• W2896520301 hasConceptScore W2896520301C2776151105 @default.
• W2896520301 hasConceptScore W2896520301C2778401633 @default.
• W2896520301 hasConceptScore W2896520301C2778857457 @default.
• W2896520301 hasConceptScore W2896520301C2778979269 @default.

• next