FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896521076> ?p ?o ?g. }

• W2896521076 endingPage "772" @default.
• W2896521076 startingPage "768" @default.
• W2896521076 abstract "Schoenberger and colleagues ( Schoenberger et al. ( 2018 ) ACS Chem. Neurosci. 9 , 298 - 305 ) recently reported attempts to demonstrate specific binding of the positron emission tomography (PET) radiotracer, [18F]GE-179, to NMDA receptors in both rats and Rhesus macaques. GE-179 did not work as expected in animal models; however, we disagree with the authors' conclusion that the [18F]GE-179 signal seems to be largely nonspecific. It is extremely challenging to demonstrate specific binding for the use-dependent NMDA receptor intrachannel ligands such as [18F]GE-179 in animals via traditional blocking, due to its low availability of target sites ( Bmax'). Schoenberger and colleagues anesthetized rats and Rhesus monkeys using isoflurane, which has an inhibitory effect on NMDA receptor function and thus would be expected to further reduce the Bmax'. The extent of glutamate release achieved in the provocation experiments is uncertain, as is whether a significant increase in NMDA receptor channel opening can be expected under anesthesia. Prior data suggest that the uptake of disubstituted arylguanidine-based ligands such as GE-179 can be reduced by phencyclidine binding site antagonists, if injection is performed in the absence of ketamine and isoflurane anesthesia, e.g., with GE-179's antecedent, CNS 5161 ( Biegon et al. ( 2007 ) Synapse 61 , 577 - 586 ), and with GMOM ( van der Doef et al. ( 2016 ) J. Cereb. Blood Flow Metab. 36 , 1111 - 1121 ). However, the extent of nonspecific uptake remains uncertain." @default.
• W2896521076 created "2018-10-26" @default.
• W2896521076 creator A5001601365 @default.
• W2896521076 creator A5002881267 @default.
• W2896521076 creator A5003551209 @default.
• W2896521076 creator A5028469602 @default.
• W2896521076 creator A5028782099 @default.
• W2896521076 creator A5038820846 @default.
• W2896521076 creator A5045287606 @default.
• W2896521076 creator A5045336469 @default.
• W2896521076 creator A5055501247 @default.
• W2896521076 creator A5059608304 @default.
• W2896521076 creator A5059872351 @default.
• W2896521076 creator A5066966667 @default.
• W2896521076 creator A5070462206 @default.
• W2896521076 creator A5072688519 @default.
• W2896521076 creator A5085428054 @default.
• W2896521076 creator A5088868208 @default.
• W2896521076 creator A5088889539 @default.
• W2896521076 date "2018-10-11" @default.
• W2896521076 modified "2023-10-09" @default.
• W2896521076 title "Comment on “<i>In Vivo</i> [¹⁸F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates”" @default.
• W2896521076 cites W1599247107 @default.
• W2896521076 cites W1972496762 @default.
• W2896521076 cites W1973053815 @default.
• W2896521076 cites W1987995313 @default.
• W2896521076 cites W1991661467 @default.
• W2896521076 cites W2004176535 @default.
• W2896521076 cites W2015775066 @default.
• W2896521076 cites W2017175377 @default.
• W2896521076 cites W2019173407 @default.
• W2896521076 cites W2023333753 @default.
• W2896521076 cites W2024677729 @default.
• W2896521076 cites W2026183028 @default.
• W2896521076 cites W2028069995 @default.
• W2896521076 cites W2032942086 @default.
• W2896521076 cites W2034169246 @default.
• W2896521076 cites W2035672582 @default.
• W2896521076 cites W2039974667 @default.
• W2896521076 cites W2042460710 @default.
• W2896521076 cites W2048455540 @default.
• W2896521076 cites W2050207993 @default.
• W2896521076 cites W2050365831 @default.
• W2896521076 cites W2055728277 @default.
• W2896521076 cites W2056493495 @default.
• W2896521076 cites W2060726951 @default.
• W2896521076 cites W2065305984 @default.
• W2896521076 cites W2067718897 @default.
• W2896521076 cites W2073422014 @default.
• W2896521076 cites W2079462982 @default.
• W2896521076 cites W2080162167 @default.
• W2896521076 cites W2086424665 @default.
• W2896521076 cites W2088183378 @default.
• W2896521076 cites W2094066700 @default.
• W2896521076 cites W2094804227 @default.
• W2896521076 cites W2110502877 @default.
• W2896521076 cites W2113632225 @default.
• W2896521076 cites W2123197195 @default.
• W2896521076 cites W2140235984 @default.
• W2896521076 cites W2147061654 @default.
• W2896521076 cites W2150230422 @default.
• W2896521076 cites W2233091796 @default.
• W2896521076 cites W2321608583 @default.
• W2896521076 cites W2398561168 @default.
• W2896521076 cites W2613699566 @default.
• W2896521076 cites W2616489368 @default.
• W2896521076 cites W2766973546 @default.
• W2896521076 cites W2802367640 @default.
• W2896521076 cites W4237954786 @default.
• W2896521076 doi "https://doi.org/10.1021/acschemneuro.8b00246" @default.
• W2896521076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30346706" @default.
• W2896521076 hasPublicationYear "2018" @default.
• W2896521076 type Work @default.
• W2896521076 sameAs 2896521076 @default.
• W2896521076 citedByCount "11" @default.
• W2896521076 countsByYear W28965210762018 @default.
• W2896521076 countsByYear W28965210762020 @default.
• W2896521076 countsByYear W28965210762021 @default.
• W2896521076 countsByYear W28965210762022 @default.
• W2896521076 crossrefType "journal-article" @default.
• W2896521076 hasAuthorship W2896521076A5001601365 @default.
• W2896521076 hasAuthorship W2896521076A5002881267 @default.
• W2896521076 hasAuthorship W2896521076A5003551209 @default.
• W2896521076 hasAuthorship W2896521076A5028469602 @default.
• W2896521076 hasAuthorship W2896521076A5028782099 @default.
• W2896521076 hasAuthorship W2896521076A5038820846 @default.
• W2896521076 hasAuthorship W2896521076A5045287606 @default.
• W2896521076 hasAuthorship W2896521076A5045336469 @default.
• W2896521076 hasAuthorship W2896521076A5055501247 @default.
• W2896521076 hasAuthorship W2896521076A5059608304 @default.
• W2896521076 hasAuthorship W2896521076A5059872351 @default.
• W2896521076 hasAuthorship W2896521076A5066966667 @default.
• W2896521076 hasAuthorship W2896521076A5070462206 @default.
• W2896521076 hasAuthorship W2896521076A5072688519 @default.
• W2896521076 hasAuthorship W2896521076A5085428054 @default.
• W2896521076 hasAuthorship W2896521076A5088868208 @default.
• W2896521076 hasAuthorship W2896521076A5088889539 @default.
• W2896521076 hasBestOaLocation W28965210762 @default.

• next