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- W2896521093 abstract "Anemia is a major health condition associated with chronic kidney disease (CKD). A key underlying cause of this disorder is iron deficiency. Although intravenous iron treatment can be beneficial in correcting CKD-associated anemia, surplus iron can be detrimental and cause complications. Excessive generation of reactive oxygen species (ROS), particularly by mitochondria, leads to tissue oxidation and damage to DNA, proteins, and lipids. Oxidative stress increase in CKD has been further implicated in the pathogenesis of vascular calcification. Iron supplementation leads to the availability of excess free iron that is toxic and generates ROS that is linked, in turn, to inflammation, endothelial dysfunction, and cardiovascular disease. Histidine is indispensable to uremic patients because of the tendency toward negative plasma histidine levels. Histidine-deficient diets predispose healthy subjects to anemia and accentuate anemia in chronic uremic patients. Histidine is essential in globin synthesis and erythropoiesis and has also been implicated in the enhancement of iron absorption from human diets. Studies have found that L-histidine exhibits antioxidant capabilities, such as scavenging free radicals and chelating divalent metal ions, hence the advocacy for its use in improving oxidative stress in CKD. The current review advances and discusses evidence for iron-induced toxicity in CKD and the mechanisms by which histidine exerts cytoprotective functions." @default.
- W2896521093 created "2018-10-26" @default.
- W2896521093 creator A5027990536 @default.
- W2896521093 creator A5057575766 @default.
- W2896521093 creator A5058692764 @default.
- W2896521093 creator A5069967566 @default.
- W2896521093 creator A5082100868 @default.
- W2896521093 date "2018-10-21" @default.
- W2896521093 modified "2023-10-03" @default.
- W2896521093 title "Protective Role of Histidine Supplementation Against Oxidative Stress Damage in the Management of Anemia of Chronic Kidney Disease" @default.
- W2896521093 cites W1496931090 @default.
- W2896521093 cites W1499828206 @default.
- W2896521093 cites W1502094105 @default.
- W2896521093 cites W1507033310 @default.
- W2896521093 cites W1507279927 @default.
- W2896521093 cites W1528179579 @default.
- W2896521093 cites W1538991079 @default.
- W2896521093 cites W1558823847 @default.
- W2896521093 cites W1576645677 @default.
- W2896521093 cites W1577235508 @default.
- W2896521093 cites W1806270188 @default.
- W2896521093 cites W1893364029 @default.
- W2896521093 cites W1917818139 @default.
- W2896521093 cites W1917969598 @default.
- W2896521093 cites W1938171328 @default.
- W2896521093 cites W1958139147 @default.
- W2896521093 cites W1966019135 @default.
- W2896521093 cites W1968364422 @default.
- W2896521093 cites W1973780224 @default.
- W2896521093 cites W1979717099 @default.
- W2896521093 cites W1980042430 @default.
- W2896521093 cites W1980995990 @default.
- W2896521093 cites W1982308118 @default.
- W2896521093 cites W1983007724 @default.
- W2896521093 cites W1984393349 @default.
- W2896521093 cites W1987928326 @default.
- W2896521093 cites W1990863512 @default.
- W2896521093 cites W1992104940 @default.
- W2896521093 cites W1996303960 @default.
- W2896521093 cites W1997578486 @default.
- W2896521093 cites W1998943227 @default.
- W2896521093 cites W1999889125 @default.
- W2896521093 cites W2000689759 @default.
- W2896521093 cites W2000837348 @default.
- W2896521093 cites W2005450858 @default.
- W2896521093 cites W2005973637 @default.
- W2896521093 cites W2006598690 @default.
- W2896521093 cites W2007172926 @default.
- W2896521093 cites W2007440356 @default.
- W2896521093 cites W2010004915 @default.
- W2896521093 cites W2010668753 @default.
- W2896521093 cites W2013308696 @default.
- W2896521093 cites W2016099094 @default.
- W2896521093 cites W2019599941 @default.
- W2896521093 cites W2023123579 @default.
- W2896521093 cites W2024395573 @default.
- W2896521093 cites W2025230695 @default.
- W2896521093 cites W2025878569 @default.
- W2896521093 cites W2027037174 @default.
- W2896521093 cites W2033803279 @default.
- W2896521093 cites W2034618758 @default.
- W2896521093 cites W2040029744 @default.
- W2896521093 cites W2045159867 @default.
- W2896521093 cites W2046124938 @default.
- W2896521093 cites W2046646032 @default.
- W2896521093 cites W2048321718 @default.
- W2896521093 cites W2049046499 @default.
- W2896521093 cites W2049808644 @default.
- W2896521093 cites W2050711948 @default.
- W2896521093 cites W2057523382 @default.
- W2896521093 cites W2058799094 @default.
- W2896521093 cites W2059754724 @default.
- W2896521093 cites W2060113651 @default.
- W2896521093 cites W2062742764 @default.
- W2896521093 cites W2068199807 @default.
- W2896521093 cites W2068798303 @default.
- W2896521093 cites W2071729123 @default.
- W2896521093 cites W2073816425 @default.
- W2896521093 cites W2079152034 @default.
- W2896521093 cites W2085784457 @default.
- W2896521093 cites W2096282875 @default.
- W2896521093 cites W2097302528 @default.
- W2896521093 cites W2097830837 @default.
- W2896521093 cites W2098124630 @default.
- W2896521093 cites W2099142274 @default.
- W2896521093 cites W2102237016 @default.
- W2896521093 cites W2105003544 @default.
- W2896521093 cites W2108858457 @default.
- W2896521093 cites W2109081740 @default.
- W2896521093 cites W2115780559 @default.
- W2896521093 cites W2123200029 @default.
- W2896521093 cites W2123555310 @default.
- W2896521093 cites W2124569473 @default.
- W2896521093 cites W2128490296 @default.
- W2896521093 cites W2130991130 @default.
- W2896521093 cites W2131182373 @default.
- W2896521093 cites W2132857214 @default.
- W2896521093 cites W2141387019 @default.