FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896521939> ?p ?o ?g. }

• W2896521939 endingPage "313" @default.
• W2896521939 startingPage "313" @default.
• W2896521939 abstract "To examine the association between phosphodiesterase type 5 (PDE5) inhibitor use and melanoma by 1) conducting a systematic review of observational studies; and 2) determining if low PDE5A gene expression in human melanoma correlated with decreased overall survival.A systematic search of observational studies examining the association between PDE5 inhibitor use and melanoma was performed through ClinicalTrials.gov, the Cochrane Library, EMBASE, PubMed, and Web of Science databases, and seven eligible studies were identified. PDE5A gene expression was analyzed with RNA sequencing data from 471 human melanoma samples obtained from The Cancer Genome Atlas.Four studies reported a positive association between PDE5 inhibitor use and melanoma, and three studies found no correlation. RNA sequencing data analysis revealed that under-expression of the PDE5A gene did not impact clinical outcomes in melanoma.There is currently no evidence to suggest that PDE5 inhibition in patients causes increased risk for melanoma. The few observational studies that demonstrated a positive association between PDE5 inhibitor use and melanoma often failed to account for major confounders. Nonetheless, the substantial evidence implicating PDE5 inhibition in the cyclic guanosine monophosphate (cGMP)-mediated melanoma pathway warrants further investigation in the clinical setting." @default.
• W2896521939 created "2018-10-26" @default.
• W2896521939 creator A5015307746 @default.
• W2896521939 creator A5022383277 @default.
• W2896521939 creator A5028451141 @default.
• W2896521939 creator A5030729248 @default.
• W2896521939 creator A5032164345 @default.
• W2896521939 creator A5073185830 @default.
• W2896521939 creator A5076958813 @default.
• W2896521939 date "2019-01-01" @default.
• W2896521939 modified "2023-10-09" @default.
• W2896521939 title "No Causal Link between Phosphodiesterase Type 5 Inhibition and Melanoma" @default.
• W2896521939 cites W1531390755 @default.
• W2896521939 cites W1568390176 @default.
• W2896521939 cites W1864178760 @default.
• W2896521939 cites W1967695112 @default.
• W2896521939 cites W1981191236 @default.
• W2896521939 cites W2009334802 @default.
• W2896521939 cites W2010913335 @default.
• W2896521939 cites W2031329108 @default.
• W2896521939 cites W2031597608 @default.
• W2896521939 cites W2043169882 @default.
• W2896521939 cites W2052555581 @default.
• W2896521939 cites W2069439351 @default.
• W2896521939 cites W2093504658 @default.
• W2896521939 cites W2101576811 @default.
• W2896521939 cites W2112789978 @default.
• W2896521939 cites W2126020984 @default.
• W2896521939 cites W2128056532 @default.
• W2896521939 cites W2141186092 @default.
• W2896521939 cites W2154683287 @default.
• W2896521939 cites W2160903204 @default.
• W2896521939 cites W2168711434 @default.
• W2896521939 cites W2188182035 @default.
• W2896521939 cites W2362741058 @default.
• W2896521939 cites W2442855507 @default.
• W2896521939 cites W2477416920 @default.
• W2896521939 cites W2513025522 @default.
• W2896521939 cites W2514799635 @default.
• W2896521939 cites W2615680972 @default.
• W2896521939 cites W2735586502 @default.
• W2896521939 cites W2775160153 @default.
• W2896521939 cites W2795613396 @default.
• W2896521939 cites W2805809745 @default.
• W2896521939 doi "https://doi.org/10.5534/wjmh.180050" @default.
• W2896521939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6704303" @default.
• W2896521939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30350485" @default.
• W2896521939 hasPublicationYear "2019" @default.
• W2896521939 type Work @default.
• W2896521939 sameAs 2896521939 @default.
• W2896521939 citedByCount "3" @default.
• W2896521939 countsByYear W28965219392020 @default.
• W2896521939 countsByYear W28965219392021 @default.
• W2896521939 countsByYear W28965219392023 @default.
• W2896521939 crossrefType "journal-article" @default.
• W2896521939 hasAuthorship W2896521939A5015307746 @default.
• W2896521939 hasAuthorship W2896521939A5022383277 @default.
• W2896521939 hasAuthorship W2896521939A5028451141 @default.
• W2896521939 hasAuthorship W2896521939A5030729248 @default.
• W2896521939 hasAuthorship W2896521939A5032164345 @default.
• W2896521939 hasAuthorship W2896521939A5073185830 @default.
• W2896521939 hasAuthorship W2896521939A5076958813 @default.
• W2896521939 hasBestOaLocation W28965219391 @default.
• W2896521939 hasConcept C126322002 @default.
• W2896521939 hasConcept C143998085 @default.
• W2896521939 hasConcept C23131810 @default.
• W2896521939 hasConcept C2776478404 @default.
• W2896521939 hasConcept C2777658100 @default.
• W2896521939 hasConcept C502942594 @default.
• W2896521939 hasConcept C60644358 @default.
• W2896521939 hasConcept C71924100 @default.
• W2896521939 hasConcept C77350462 @default.
• W2896521939 hasConcept C86803240 @default.
• W2896521939 hasConcept C95190672 @default.
• W2896521939 hasConceptScore W2896521939C126322002 @default.
• W2896521939 hasConceptScore W2896521939C143998085 @default.
• W2896521939 hasConceptScore W2896521939C23131810 @default.
• W2896521939 hasConceptScore W2896521939C2776478404 @default.
• W2896521939 hasConceptScore W2896521939C2777658100 @default.
• W2896521939 hasConceptScore W2896521939C502942594 @default.
• W2896521939 hasConceptScore W2896521939C60644358 @default.
• W2896521939 hasConceptScore W2896521939C71924100 @default.
• W2896521939 hasConceptScore W2896521939C77350462 @default.
• W2896521939 hasConceptScore W2896521939C86803240 @default.
• W2896521939 hasConceptScore W2896521939C95190672 @default.
• W2896521939 hasIssue "3" @default.
• W2896521939 hasLocation W28965219391 @default.
• W2896521939 hasLocation W28965219392 @default.
• W2896521939 hasLocation W28965219393 @default.
• W2896521939 hasLocation W28965219394 @default.
• W2896521939 hasLocation W28965219395 @default.
• W2896521939 hasOpenAccess W2896521939 @default.
• W2896521939 hasPrimaryLocation W28965219391 @default.
• W2896521939 hasRelatedWork W1970565537 @default.
• W2896521939 hasRelatedWork W2053234536 @default.
• W2896521939 hasRelatedWork W2768202459 @default.
• W2896521939 hasRelatedWork W3021809565 @default.
• W2896521939 hasRelatedWork W3109537979 @default.

• next