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• W2896523360 abstract "The core criterion for Parkinson's disease dementia ( PDD ) is the impairment in activities of daily living ( ADL ) function primarily caused by cognitive, not motor symptoms. There is evidence to assume that mild ADL impairments in mild cognitive impairment ( PD ‐ MCI ) characterize those patients at high risk for dementia. Data of 216 Parkinson's disease ( PD ) patients assessed with comprehensive motor and neuropsychological assessments were analysed. Based on linear regression models, subscores of the Functional Activities Questionnaire ( FAQ ) primarily reflecting patients’ global cognitive status ( FAQ C ) or PD ‐related motor severity ( FAQ M ) were developed. A quotient ( FAQ Q ) of both scores was calculated, with values >1 indicating more cognitive‐ compared to motor‐driven ADL impairment. Both FAQ C and FAQ M scores were higher in PD ‐ MCI than cognitively normal ( PD ‐ CN ) patients, indicating more severe cognitive‐ and motor‐driven ADL impairments in this group. One third (31.6%) of the PD ‐ MCI group had a FAQ Q score >1, which was significantly different from patients with PD ‐ CN ( p = .02). PD ‐ MCI patients with an FAQ Q score >1 were more impaired on tests assessing attention ( p = .019) and language ( p = .033) compared to PD ‐ MCI patients with lower FAQ Q values. The differentiation between cognitive‐ and motor‐driven ADL is important, as the loss of functional capacity is the defining factor for a diagnosis of PDD . We were able to differentiate the cognitive‐driven from the motor‐driven ADL impairments for the FAQ . PD ‐ MCI patients with more cognitive‐ compared to motor‐driven ADL impairments may pose a risk group for conversion to PDD and can be targeted for early treatments." @default.
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• W2896523360 date "2018-10-15" @default.
• W2896523360 modified "2023-09-26" @default.
• W2896523360 title "Assessment of cognitive‐driven activity of daily living impairment in non‐demented Parkinson's patients" @default.
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• W2896523360 doi "https://doi.org/10.1111/jnp.12173" @default.
• W2896523360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320954" @default.
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