FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896528779> ?p ?o ?g. }

• W2896528779 abstract "Prior small studies have shown increased expression of sperm protein 17 (Sp17) in epithelial ovarian cancer (EOC) tissue and suggest Sp17 as a potential biomarker for EOC. However, how Sp17 expression varies with histology, grade, and stage of EOC and its expression in other ovarian neoplasms has not been defined. It is unknown whether patients with EOC have elevated serum Sp17 levels or if Sp17 expression is associated with survival outcomes.The study included 982 patients with benign, borderline, and malignant ovarian neoplasms and normal ovary. There were 878 patients with tissue only, 39 with serum only, and 65 with matching serum and tissue. Immunohistochemical (IHC) staining with anti-Sp17 antibody was performed on tissue specimens and the intensity scored as weak, moderate, or strong. A sandwich enzyme-linked immunosorbent assay (ELISA) was performed to measure Sp17 sera concentrations.Sp17 expression was most commonly seen in serous cystadenomas (83%) and serous borderline tumors (100%). Of the 773 EOC specimens, 223 (30%) expressed Sp17. Grade and histology were significantly associated with Sp17 expression among EOC specimens (p < 0.001) on both univariate and multivariable analysis, with grade 1 serous adenocarcinomas showing the highest expression (51%). Sp17 expression was limited in other benign and non-epithelial malignant neoplasms. Neither Sp17 tissue expression nor serum concentration correlated with survival outcomes. Serum concentrations were higher in patients with Sp17 tissue expression, and the highest concentrations were noted among patients with serous and clear cell adenocarcinomas.Sp17 is highly expressed in benign, borderline, and low grade malignant serous ovarian neoplasms and can be quantified in serum. Sp17 expression may have diagnostic significance in this subset of patients." @default.
• W2896528779 created "2018-10-26" @default.
• W2896528779 creator A5013274725 @default.
• W2896528779 creator A5022084686 @default.
• W2896528779 creator A5028911096 @default.
• W2896528779 creator A5029908328 @default.
• W2896528779 creator A5048611754 @default.
• W2896528779 creator A5060534243 @default.
• W2896528779 creator A5067387322 @default.
• W2896528779 creator A5072088187 @default.
• W2896528779 creator A5075566972 @default.
• W2896528779 creator A5076753269 @default.
• W2896528779 creator A5081037579 @default.
• W2896528779 creator A5082245952 @default.
• W2896528779 date "2018-10-11" @default.
• W2896528779 modified "2023-10-14" @default.
• W2896528779 title "Validity and prognostic significance of sperm protein 17 as a tumor biomarker for epithelial ovarian cancer: a retrospective study" @default.
• W2896528779 cites W1598446361 @default.
• W2896528779 cites W1986174251 @default.
• W2896528779 cites W1987664890 @default.
• W2896528779 cites W1990834696 @default.
• W2896528779 cites W1996926182 @default.
• W2896528779 cites W2011065238 @default.
• W2896528779 cites W2011308482 @default.
• W2896528779 cites W2020247695 @default.
• W2896528779 cites W2026842096 @default.
• W2896528779 cites W2039704180 @default.
• W2896528779 cites W2048572064 @default.
• W2896528779 cites W2052024480 @default.
• W2896528779 cites W2053263835 @default.
• W2896528779 cites W2070761767 @default.
• W2896528779 cites W2071541869 @default.
• W2896528779 cites W2083802138 @default.
• W2896528779 cites W2086757750 @default.
• W2896528779 cites W2093252833 @default.
• W2896528779 cites W2100416170 @default.
• W2896528779 cites W2101582566 @default.
• W2896528779 cites W2106439593 @default.
• W2896528779 cites W2115421008 @default.
• W2896528779 cites W2120800350 @default.
• W2896528779 cites W2124951001 @default.
• W2896528779 cites W2131593373 @default.
• W2896528779 cites W2137088550 @default.
• W2896528779 cites W2140373765 @default.
• W2896528779 cites W2257836175 @default.
• W2896528779 cites W2305551225 @default.
• W2896528779 cites W2521499298 @default.
• W2896528779 cites W4245049346 @default.
• W2896528779 doi "https://doi.org/10.1186/s12885-018-4880-x" @default.
• W2896528779 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6182788" @default.
• W2896528779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30309325" @default.
• W2896528779 hasPublicationYear "2018" @default.
• W2896528779 type Work @default.
• W2896528779 sameAs 2896528779 @default.
• W2896528779 citedByCount "6" @default.
• W2896528779 countsByYear W28965287792019 @default.
• W2896528779 countsByYear W28965287792021 @default.
• W2896528779 countsByYear W28965287792022 @default.
• W2896528779 countsByYear W28965287792023 @default.
• W2896528779 crossrefType "journal-article" @default.
• W2896528779 hasAuthorship W2896528779A5013274725 @default.
• W2896528779 hasAuthorship W2896528779A5022084686 @default.
• W2896528779 hasAuthorship W2896528779A5028911096 @default.
• W2896528779 hasAuthorship W2896528779A5029908328 @default.
• W2896528779 hasAuthorship W2896528779A5048611754 @default.
• W2896528779 hasAuthorship W2896528779A5060534243 @default.
• W2896528779 hasAuthorship W2896528779A5067387322 @default.
• W2896528779 hasAuthorship W2896528779A5072088187 @default.
• W2896528779 hasAuthorship W2896528779A5075566972 @default.
• W2896528779 hasAuthorship W2896528779A5076753269 @default.
• W2896528779 hasAuthorship W2896528779A5081037579 @default.
• W2896528779 hasAuthorship W2896528779A5082245952 @default.
• W2896528779 hasBestOaLocation W28965287791 @default.
• W2896528779 hasConcept C121608353 @default.
• W2896528779 hasConcept C126322002 @default.
• W2896528779 hasConcept C142724271 @default.
• W2896528779 hasConcept C146357865 @default.
• W2896528779 hasConcept C150173356 @default.
• W2896528779 hasConcept C151730666 @default.
• W2896528779 hasConcept C204232928 @default.
• W2896528779 hasConcept C2780140570 @default.
• W2896528779 hasConcept C2780427987 @default.
• W2896528779 hasConcept C2781197716 @default.
• W2896528779 hasConcept C55493867 @default.
• W2896528779 hasConcept C63363279 @default.
• W2896528779 hasConcept C71924100 @default.
• W2896528779 hasConcept C86803240 @default.
• W2896528779 hasConceptScore W2896528779C121608353 @default.
• W2896528779 hasConceptScore W2896528779C126322002 @default.
• W2896528779 hasConceptScore W2896528779C142724271 @default.
• W2896528779 hasConceptScore W2896528779C146357865 @default.
• W2896528779 hasConceptScore W2896528779C150173356 @default.
• W2896528779 hasConceptScore W2896528779C151730666 @default.
• W2896528779 hasConceptScore W2896528779C204232928 @default.
• W2896528779 hasConceptScore W2896528779C2780140570 @default.
• W2896528779 hasConceptScore W2896528779C2780427987 @default.
• W2896528779 hasConceptScore W2896528779C2781197716 @default.
• W2896528779 hasConceptScore W2896528779C55493867 @default.
• W2896528779 hasConceptScore W2896528779C63363279 @default.
• W2896528779 hasConceptScore W2896528779C71924100 @default.

• next