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- W2896529033 abstract "Amac: Son yillarda; kucuk hucreli disi akciger karsinom (KHDAK)’lu hastalarda, adjuvan platin bazli kombinasyon kemoterapisinin etkinligi uzerinde Excision-Repair-Cross-Complementing-Grup-1 (ERCC1) geni ekspresyon duzeyinin ongorucu deger tasidigini belirten calismalar bildirilmekle birlikte konu hakkindaki degeri halen tartismalidir. Calismamizda akciger rezeksiyonu sonrasi platin bazli kemoterapi uygulanan hastalarda ERCC1 ekspresyon duzeyinin belirlenmesinde immunohistokimyasal analiz (IHK) ve gercek zamanli polimeraz zincir reaksiyonu (RT-PCR) yontemlerinin etkinliginin karsilastirilmasi ve calisma sonunda elde edilen verilerin tedavi yanitini ongormedeki etkinliginin incelenmesi hedeflendi. Gerec ve Yontem: Calismamiz prospektif ve tanimlayici ozelliktedir. Ocak 2011- Ocak 2014 tarihleri arasinda Dokuz Eylul Universitesi Gogus Cerrahisi Klinigi’nde KHDAK nedeniyle opere edilen ve calisma kriterlerine uyan hastalar dahil edildi. Hastalardaki ERCC1 ekspresyon duzeyleri RT-PCR ve IHK ile analiz edildi. ERCC1 ekspresyonunun prediktif degeri, sonuclarin nuks ve sagkalim acisindan istatistiksel olarak incelenmesi ile degerlendirildi. Bulgular: Calisma 17 olgu uzerinden yurutuldu. Olgularin ortalama yasi 59.82±6.36 yildi. Uc olguda nuks gozlenirken, iki yillik sagkalim %82.4 idi. RT-PCR ile analizi ile %64.70 olguda tumor dokusunda ERCC1 ekspresyon duzeyinin normal dokuya gore daha yuksek oldugu belirlendi. IHK analizi ile olgularin %35.29’unda guclu ekspresyon gozlendi. Olgularin RT-PCR ile IHK skor ortalamalari arasindaki iliski anlamli degildi (p=0.14). Hastalarin nuks gelisimi ile RT-PCR skorunun korele oldugu (r=-0.29), IHK skorlamasinin ise cok zayif korelasyon (r=0.13) gosterdigi belirlendi. Sonuc: Calismamiz, KHDAK’ da ERCC1 ekspresyon duzeyinin RT-PCR ile belirlenmesinin IHK ile belirlenmesine gore daha guvenilir olabilecegini desteklemistir. Ancak daha kesin yorumlar yapabilmek icin cok merkezli, genis olgu serilerinde calismalara ihtiyac vardir." @default.
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- W2896529033 date "2018-01-01" @default.
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- W2896529033 title "Is It Useful To Determine ERCC1 Expression In Early Stage Non-Small Cell Lung Carcinomas?" @default.
- W2896529033 doi "https://doi.org/10.5505/deutfd.2018.05902" @default.
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