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- W2896530034 abstract "Objective: to determine the markers of oxidative stress in full-term newborns considering the degree of severity of general condition disorders and functional renal state.Material and methods. A comprehensive clinical-paraclinical examination of 147 term newborns was conducted including 41 children with moderate disorders of general condition; 36 children with severe disorders of general condition without acute kidney lesion (AKL); 30 children with severe disorders of general condition with AKL; 40 healthy children. Intensity of oxidative protein modification (OPM) in the blood plasma, malone aldehyde (MA) in erythrocytes, ceruloplasmin (CP) level and catalase activity in the blood plasma were determined.Results. In case of moderate oxygen insufficiency term newborns develop compensatory increase of CP level and moderate decrease of catalase activity together with increased intensity of MA in erythrocytes enabling to ensure relative stability of vital functions. Formations of severe perinatal pathology was associated with excessive uncontrolled activation of the processes of lipid peroxide oxidation and protein oxidation against the ground of inhibited activity of both presented links in the antioxidant protective system (AOPS). One of the pathogenic mechanisms provoking formation of severe kidney dysfunction in critically sick term children is pathologic oxidative stress which is evidenced by excessive activation of the processes of protein and lipid peroxidation together with minimal value of ceruloplasmin level.Conclusions. Disorders of mutually regulating relations between pro-oxidant and antioxidant systems under conditions of oxygen deficiency and pathologic oxidative stress are universal and non-specific mechanism of formation of severe renal dysfunction." @default.
- W2896530034 created "2018-10-26" @default.
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- W2896530034 date "2018-05-24" @default.
- W2896530034 modified "2023-10-18" @default.
- W2896530034 title "Markers of oxidative stress in full-term newborns with renal dysfunction" @default.
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- W2896530034 doi "https://doi.org/10.24061/2413-0737.xxii.2.86.2018.25" @default.
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