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- W2896536135 abstract "Significance Despite the initial success of therapeutic agents targeting the RAS / MAP kinase and PI3K/AKT/mTOR signalling networks in oncology, development of acquired resistance to such therapeutics represents a significant challenge in successful disease management. BCL-2–associated death promoter (BAD) is a common and core downstream molecule for both the RAS / MAP kinase and PI3K/AKT/mTOR pathways and regulates cancer cell survival. In its unphosphorylated state, BAD sequesters BCL-2, which results in BAK/BAX activation and apoptosis. Herein, we identified and characterized a small molecule which specifically inhibits BAD phosphorylation on Ser99. This molecule may be therapeutically useful, either alone or in combination, to delay or obviate the development of resistance to other therapeutic agents." @default.
- W2896536135 created "2018-10-26" @default.
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- W2896536135 date "2018-10-11" @default.
- W2896536135 modified "2023-10-11" @default.
- W2896536135 title "Discovery of a small-molecule inhibitor of specific serine residue BAD phosphorylation" @default.
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- W2896536135 doi "https://doi.org/10.1073/pnas.1804897115" @default.
- W2896536135 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6217419" @default.
- W2896536135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30309962" @default.
- W2896536135 hasPublicationYear "2018" @default.
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