FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896536443> ?p ?o ?g. }

• W2896536443 endingPage "137" @default.
• W2896536443 startingPage "129" @default.
• W2896536443 abstract "<b><i>Objective:</i></b> Interaction between the nervous and immune systems may influence emotions, ultimately affecting human health. Cytokines may play a role in developing emotional dysregulation as in alexithymia, a personality construct characterized by the subclinical inability to identify and describe emotions, often associated with several psychiatric and psychosomatic disorders. The proinflammatory cytokine IL-18, with a recognized role in brain functions, may influence serotonin metabolism and appears to be associated with alexithymia. Healthy individuals carrying the long allele (L) of the serotonin transporter gene polymorphic region (5-HTTLPR), and thus having lower concentrations of serotonin in the synaptic cleft, show a greater tendency toward alexithymia, with some gender differences. To explore a potential physiological interaction between IL-18, serotonin neurotransmission, and alexithymia, we investigated whether IL-18 serum levels and 5-HTTLPR are linked to alexithymic traits in healthy subjects. <b><i>Methods:</i></b> We measured IL-18 serum levels in 115 Italian-Caucasian healthy subjects genotyped for 5-HTTLPR allele variants, divided by gender and assessed for alexithymia scores using the 20-item Toronto Alexithymia Scale. <b><i>Results:</i></b> IL-18 levels are significantly more elevated in individuals with the LL genotype (<i>n</i> = 25) than in carriers of the short allele (<i>n</i> = 90, <i>p</i> = 0.0073). Specifically, in LL males (<i>n</i> = 11), i.e., the group with the most relevant increase in IL-18, cytokine values positively correlated with difficulty identifying feelings, which is a component of alexithymia (<i>r</i> = 0.634, <i>p</i> = 0.036). <b><i>Conclusions:</i></b> These results indicate a possible novel interaction between IL-18 and the serotoninergic system to mediate emotional unawareness, suggesting putative biological predictors of emotional dysregulation, which in turn can act as a risk factor for a variety of medical conditions in susceptible subjects." @default.
• W2896536443 created "2018-10-26" @default.
• W2896536443 creator A5004257546 @default.
• W2896536443 creator A5011836054 @default.
• W2896536443 creator A5020865557 @default.
• W2896536443 creator A5021425942 @default.
• W2896536443 creator A5031284141 @default.
• W2896536443 creator A5046603443 @default.
• W2896536443 creator A5060389826 @default.
• W2896536443 creator A5091780356 @default.
• W2896536443 creator A5091875218 @default.
• W2896536443 date "2018-01-01" @default.
• W2896536443 modified "2023-10-02" @default.
• W2896536443 title "IL-18 Serum Levels and Variants of the Serotonin Transporter Gene Are Related to Awareness of Emotions in Healthy Subjects: A Preliminary Study" @default.
• W2896536443 cites W169828472 @default.
• W2896536443 cites W1826616105 @default.
• W2896536443 cites W1933084657 @default.
• W2896536443 cites W1971797728 @default.
• W2896536443 cites W1972727110 @default.
• W2896536443 cites W1977135749 @default.
• W2896536443 cites W1978464019 @default.
• W2896536443 cites W1997720968 @default.
• W2896536443 cites W1999544247 @default.
• W2896536443 cites W2006009013 @default.
• W2896536443 cites W2007421151 @default.
• W2896536443 cites W2010145371 @default.
• W2896536443 cites W2022634896 @default.
• W2896536443 cites W2026033751 @default.
• W2896536443 cites W2027168220 @default.
• W2896536443 cites W2032867662 @default.
• W2896536443 cites W2033835666 @default.
• W2896536443 cites W2039728135 @default.
• W2896536443 cites W2045766291 @default.
• W2896536443 cites W2046298606 @default.
• W2896536443 cites W2046551891 @default.
• W2896536443 cites W2048253779 @default.
• W2896536443 cites W2049865797 @default.
• W2896536443 cites W2051068515 @default.
• W2896536443 cites W2056573452 @default.
• W2896536443 cites W2061378977 @default.
• W2896536443 cites W2064856766 @default.
• W2896536443 cites W2067628694 @default.
• W2896536443 cites W2069003342 @default.
• W2896536443 cites W2081716655 @default.
• W2896536443 cites W2089300880 @default.
• W2896536443 cites W2097147259 @default.
• W2896536443 cites W2098631023 @default.
• W2896536443 cites W2099218859 @default.
• W2896536443 cites W2100066845 @default.
• W2896536443 cites W2100230238 @default.
• W2896536443 cites W2114613490 @default.
• W2896536443 cites W2126589263 @default.
• W2896536443 cites W2126795224 @default.
• W2896536443 cites W2140634600 @default.
• W2896536443 cites W2143066408 @default.
• W2896536443 cites W2149463687 @default.
• W2896536443 cites W2151135161 @default.
• W2896536443 cites W2152119538 @default.
• W2896536443 cites W2156220037 @default.
• W2896536443 cites W2166667138 @default.
• W2896536443 cites W2167848374 @default.
• W2896536443 cites W2173140591 @default.
• W2896536443 cites W2246245122 @default.
• W2896536443 doi "https://doi.org/10.1159/000492030" @default.
• W2896536443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30326484" @default.
• W2896536443 hasPublicationYear "2018" @default.
• W2896536443 type Work @default.
• W2896536443 sameAs 2896536443 @default.
• W2896536443 citedByCount "3" @default.
• W2896536443 countsByYear W28965364432021 @default.
• W2896536443 countsByYear W28965364432022 @default.
• W2896536443 crossrefType "journal-article" @default.
• W2896536443 hasAuthorship W2896536443A5004257546 @default.
• W2896536443 hasAuthorship W2896536443A5011836054 @default.
• W2896536443 hasAuthorship W2896536443A5020865557 @default.
• W2896536443 hasAuthorship W2896536443A5021425942 @default.
• W2896536443 hasAuthorship W2896536443A5031284141 @default.
• W2896536443 hasAuthorship W2896536443A5046603443 @default.
• W2896536443 hasAuthorship W2896536443A5060389826 @default.
• W2896536443 hasAuthorship W2896536443A5091780356 @default.
• W2896536443 hasAuthorship W2896536443A5091875218 @default.
• W2896536443 hasConcept C104317684 @default.
• W2896536443 hasConcept C118552586 @default.
• W2896536443 hasConcept C126322002 @default.
• W2896536443 hasConcept C134018914 @default.
• W2896536443 hasConcept C15744967 @default.
• W2896536443 hasConcept C170493617 @default.
• W2896536443 hasConcept C180754005 @default.
• W2896536443 hasConcept C2775864247 @default.
• W2896536443 hasConcept C2778897192 @default.
• W2896536443 hasConcept C2780559815 @default.
• W2896536443 hasConcept C5284366 @default.
• W2896536443 hasConcept C54355233 @default.
• W2896536443 hasConcept C71924100 @default.
• W2896536443 hasConcept C86803240 @default.
• W2896536443 hasConceptScore W2896536443C104317684 @default.
• W2896536443 hasConceptScore W2896536443C118552586 @default.
• W2896536443 hasConceptScore W2896536443C126322002 @default.

• next