FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896544713> ?p ?o ?g. }

• W2896544713 endingPage "6428" @default.
• W2896544713 startingPage "6413" @default.
• W2896544713 abstract "Photothermal exposure of polydopamine-coated branched Au-Ag nanoparticles induces cell cycle arrest, apoptosis, and autophagy in human bladder cancer cells Xiaoming Zhao,1,* Tianyang Qi,1,* Chenfei Kong,1 Miao Hao,1 Yuqian Wang,1 Jing Li,1 Baocai Liu,2 Yiyao Gao,1 Jinlan Jiang1 1Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun, China; 2Department of Radiation Oncology, China-Japan Union Hospital of Jilin University, Changchun, China *These authors contributed equally to this work Purpose: Polydopamine-coated branched Au–Ag nanoparticles (Au–Ag@PDA NPs) exhibit good structural stability, biocompatibility, and photothermal performance, along with potential anticancer efficacy. Here, we investigated the cytotoxicity of Au–Ag@PDA NPs against human bladder cancer cells (T24 cells) in vitro and in vivo, as well as the underlying molecular mechanisms of photothermal therapy-induced T24 cell death.Materials and methods: T24 cells were treated with different doses of Au–Ag@PDA NPs followed by 808 nm laser irradiation, and the effects on cell proliferation, cell cycle, apoptosis, and autophagy were analyzed. To confirm the mechanisms of inhibition, real-time PCR and Western blot analysis were used to evaluate markers of cell cycle, apoptosis, autophagy, and the AKT/ERK signaling pathway. Moreover, we evaluated the effects of the treatment on mitochondrial membrane potential and ROS generation to confirm the underlying mechanisms of inhibition. Finally, we tested the T24 tumor inhibitory effects of Au–Ag@PDA NPs plus laser irradiation in vivo using a xenograft mouse model.Results: Au–Ag@PDA NPs, with appropriate laser irradiation, dramatically inhibited the proliferation of T24 cells, altered the cell cycle distribution by increasing the proportion of cells in the S phase, induced cell apoptosis by activating the mitochondria-mediated intrinsic pathway, and triggered a robust autophagy response in T24 cells. Moreover, Au–Ag@PDA NPs decreased the expression of phosphorylated AKT and ERK and promoted the production of ROS that function upstream of apoptosis and autophagy. In addition, Au–Ag@PDA NP-mediated photothermolysis also significantly suppressed tumor growth in vivo.Conclusion: This preclinical study can provide a mechanistic basis for Au–Ag@PDA NP-mediated photothermal therapy toward promotion of this method in the clinical treatment of bladder cancer. Keywords: nanoparticles, photothermal therapy, near-infrared laser, cell cycle, apoptosis, autophagy" @default.
• W2896544713 created "2018-10-26" @default.
• W2896544713 creator A5004397898 @default.
• W2896544713 creator A5012677271 @default.
• W2896544713 creator A5013353643 @default.
• W2896544713 creator A5043741658 @default.
• W2896544713 creator A5061153065 @default.
• W2896544713 creator A5070432677 @default.
• W2896544713 creator A5074673516 @default.
• W2896544713 creator A5087761966 @default.
• W2896544713 creator A5089578482 @default.
• W2896544713 date "2018-10-01" @default.
• W2896544713 modified "2023-09-25" @default.
• W2896544713 title "Photothermal exposure of polydopamine-coated branched Au&ndash;Ag nanoparticles induces cell cycle arrest, apoptosis, and autophagy in human bladder cancer cells" @default.
• W2896544713 cites W1521411817 @default.
• W2896544713 cites W1544564404 @default.
• W2896544713 cites W1678768103 @default.
• W2896544713 cites W1885097981 @default.
• W2896544713 cites W1964483580 @default.
• W2896544713 cites W1993467990 @default.
• W2896544713 cites W1997155563 @default.
• W2896544713 cites W1997287521 @default.
• W2896544713 cites W2000972943 @default.
• W2896544713 cites W2021505095 @default.
• W2896544713 cites W2027121631 @default.
• W2896544713 cites W2033156964 @default.
• W2896544713 cites W2035864800 @default.
• W2896544713 cites W2036621981 @default.
• W2896544713 cites W2043303702 @default.
• W2896544713 cites W2048225778 @default.
• W2896544713 cites W2063470712 @default.
• W2896544713 cites W2076453831 @default.
• W2896544713 cites W2097788151 @default.
• W2896544713 cites W2099562625 @default.
• W2896544713 cites W2112323649 @default.
• W2896544713 cites W2113253343 @default.
• W2896544713 cites W2113591972 @default.
• W2896544713 cites W2120287782 @default.
• W2896544713 cites W2124688681 @default.
• W2896544713 cites W2147352903 @default.
• W2896544713 cites W2167737820 @default.
• W2896544713 cites W2195849363 @default.
• W2896544713 cites W2232623525 @default.
• W2896544713 cites W2308572248 @default.
• W2896544713 cites W2389554188 @default.
• W2896544713 cites W2465156857 @default.
• W2896544713 cites W2486331155 @default.
• W2896544713 cites W2575532686 @default.
• W2896544713 cites W2744575417 @default.
• W2896544713 cites W2782775245 @default.
• W2896544713 cites W4230724532 @default.
• W2896544713 cites W818507905 @default.
• W2896544713 doi "https://doi.org/10.2147/ijn.s174349" @default.
• W2896544713 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6199236" @default.
• W2896544713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30410328" @default.
• W2896544713 hasPublicationYear "2018" @default.
• W2896544713 type Work @default.
• W2896544713 sameAs 2896544713 @default.
• W2896544713 citedByCount "51" @default.
• W2896544713 countsByYear W28965447132019 @default.
• W2896544713 countsByYear W28965447132020 @default.
• W2896544713 countsByYear W28965447132021 @default.
• W2896544713 countsByYear W28965447132022 @default.
• W2896544713 countsByYear W28965447132023 @default.
• W2896544713 crossrefType "journal-article" @default.
• W2896544713 hasAuthorship W2896544713A5004397898 @default.
• W2896544713 hasAuthorship W2896544713A5012677271 @default.
• W2896544713 hasAuthorship W2896544713A5013353643 @default.
• W2896544713 hasAuthorship W2896544713A5043741658 @default.
• W2896544713 hasAuthorship W2896544713A5061153065 @default.
• W2896544713 hasAuthorship W2896544713A5070432677 @default.
• W2896544713 hasAuthorship W2896544713A5074673516 @default.
• W2896544713 hasAuthorship W2896544713A5087761966 @default.
• W2896544713 hasAuthorship W2896544713A5089578482 @default.
• W2896544713 hasBestOaLocation W28965447131 @default.
• W2896544713 hasConcept C105696609 @default.
• W2896544713 hasConcept C121608353 @default.
• W2896544713 hasConcept C126322002 @default.
• W2896544713 hasConcept C1491633281 @default.
• W2896544713 hasConcept C150903083 @default.
• W2896544713 hasConcept C171250308 @default.
• W2896544713 hasConcept C182606246 @default.
• W2896544713 hasConcept C185592680 @default.
• W2896544713 hasConcept C190283241 @default.
• W2896544713 hasConcept C191897082 @default.
• W2896544713 hasConcept C192562407 @default.
• W2896544713 hasConcept C203522944 @default.
• W2896544713 hasConcept C207001950 @default.
• W2896544713 hasConcept C2777230088 @default.
• W2896544713 hasConcept C29537977 @default.
• W2896544713 hasConcept C31573885 @default.
• W2896544713 hasConcept C502942594 @default.
• W2896544713 hasConcept C55493867 @default.
• W2896544713 hasConcept C71924100 @default.
• W2896544713 hasConcept C86803240 @default.
• W2896544713 hasConcept C96232424 @default.
• W2896544713 hasConceptScore W2896544713C105696609 @default.
• W2896544713 hasConceptScore W2896544713C121608353 @default.

• next