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• W2896546721 abstract "PET using Tau tracers can guide clinical diagnosis of dementia, but no visual approach has been described for qualitative interpretation so far. We aimed to identify an accurate visual method for the qualitative evaluation of 18F-AV-1451 Tau PET in clinical settings. A heterogeneous sample of 60 subjects (Table 1) scanned with 18F-AV-1451 PET was evaluated. All tau PET SUVR images were qualitatively interpreted using 4 rating scales. Three rating scales visually assessed 18F-AV-1451 uptake in 7 cortical regions (medial, inferior and lateral temporal, medial and lateral parietal, frontal and occipital) either by presence/absence of uptake or on a severity scale, from 0 to 2 and 0 to 3. The fourth rating scale looked at 18F-AV-1451 uptake in 3 regions corresponding to the Braak stages (Braak I/II, III/IV and V/VI). The results of the visual interpretation were compared to the average global 18F-AV-1451 SUVR as well as amyloid status and clinical diagnosis. The rating scale providing best correlations with global tau quantification was chosen for further analysis. A second reader independently interpreted the 60 scans and inter-rater agreement was assessed. Final scores of all visual rating scales were significantly and strongly associated with quantification of global 18F-AV-1451 uptake (Table 2). The strongest correlation was found with the scale allowing differentiation between mild, moderate and intense uptake across 7 regions (correlation coefficient = 0.92). As expected, mean visual rating scores within each diagnostic category were lower for amyloid negative subjects than for amyloid positive subjects. Moreover, we found an increasing trend directly correlated with diagnosis, with controls having the lowest, MCI an intermediate, and AD the highest values (Figure 1 and Table 3). Two-way ANOVA model confirmed that both clinical diagnosis (p<0.001) and PIB status (p<0.001) independently contributed to the visual score. Inter-rater agreement was excellent (linear weighted Kappa 0.833; correlation coefficient 0.946; R2 0.915 – Figure 2). Visual illustration of scores distribution based on diagnosis and amyloid status using the 0 to 21 scale (4-point scale). Linear regression analysis showing inter-rater agreement using the 0 to 14 scale (3-point scale). Our data show that visual rating scales strongly correlate with tau SUVR quantification, particularly when allowing differentiation between mild, moderate and intense uptake. This is a reliable, easily reproducible and promising alternative approach to tau measurement in clinical settings." @default.
• W2896546721 created "2018-10-26" @default.
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• W2896546721 date "2018-07-01" @default.
• W2896546721 modified "2023-09-30" @default.
• W2896546721 title "P2‐373: EVALUATION OF VISUAL INTERPRETATION METHODS FOR TAU PET IMAGING" @default.
• W2896546721 doi "https://doi.org/10.1016/j.jalz.2018.06.1064" @default.
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