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- W2896547825 abstract "Cognitive Reserve (CR) is a concept derived from the repeated discrepancies between the degree of brain pathology and the clinical manifestation of it. There are several surrogate markers for CR, including education, however they have innate limitations. Here, we propose an intuitive model to estimate the CR based on its original definition, encompassing brain pathology, demographics and genetic factors. Neural substrates of CR from the perspective of network topologies and functional connectivity were examined. Total 79 AD spectrum subjects underwent 3D T1-weighted, resting-state fMRI, and tau (THK-5351) and amyloid (Florbetaben) PET. We hypothesized CR as a residual of actual cognitive performance and expected performance from the pathology, demographics and genetic factor. Then, we validated this measure using education as a typical CR proxy. We performed graph analysis to investigate the association between different level of network characteristics and our CR marker. Higher CR was associated with a greater nodal strength, nodal clustering coefficient and local efficiency of Rt. middle temporal pole. One cluster of edges centered on the Rt. middle temporal pole as persistent cluster significantly correlated with CR. CR had association with the interhemispheric functional connectivity between Lt. frontoinsular and Rt. temporal lobes. This study demonstrated that Rt. middle temporal pole could be a center for neural substrates associated with CR. In addition, strong inter-hemispheric connection between Lt. frontoinsular and Rt. temporal lobes may provide an underlying basis for CR. Multimodal imaging and network perspectives can help give insight into the research about CR." @default.
- W2896547825 created "2018-10-26" @default.
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- W2896547825 date "2018-07-01" @default.
- W2896547825 modified "2023-10-16" @default.
- W2896547825 title "P3‐433: NEURAL SUBSTRATES OF COGNITIVE RESERVE IN THE ALZHEIMER'S DISEASE SPECTRUM" @default.
- W2896547825 doi "https://doi.org/10.1016/j.jalz.2018.06.1796" @default.
- W2896547825 hasPublicationYear "2018" @default.
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