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• W2896548363 abstract "Introduction: Few research studies have investigated neuropsychological domains beyond IQ in pediatric cerebral sinovenous thrombosis (CSVT). Additionally, prior studies have contained small sample sizes making generalization of results difficult. This study investigates a broad set of neuropsychological domains in pediatric CSVT and identifies predictors of poor outcomes. Hypothesis: Children with CSVT were predicted to have worse cognitive outcomes compared to the normative sample. Earlier age at CSVT and the presence of acute symptoms associated with CNS dysfunction (e.g., altered mental status, aphasia, ataxia, seizure, and hemiparesis) were also hypothesized to predict worse long-term outcomes. Methods: 20 children (mean age = 15.6 years) who suffered a CSVT during childhood (range = 3.6 to 18.0 years) participated in this study. Children completed a comprehensive neuropsychological battery and parents completed several standardized behavioral questionnaires. Testing was completed at least 6 months post-CSVT. Data were analyzed using one-sample t -tests and ANOVA. Results: Children with CSVT had significantly greater problems on measures of mood, behavior, visual-motor integration, and processing speed compared to the normative sample (all p -values < 0.05). There were also trends for children with CSVT to have poorer performance on measures of confrontation naming ( p = 0.051), sentence repetition ( p = 0.064), and metacognition ( p = 0.057). Age at the time of CSVT was a significant predictor, such that older age at CSVT was associated with poorer single word reading and poorer visual-motor integration, but higher adaptive functioning. In these preliminary findings, acute symptoms associated with CNS dysfunction did not significantly predict outcomes. Conclusions: To our knowledge, these findings represent the largest study to date investigating a broad set of neuropsychological domains following pediatric CSVT. This population demonstrated weaknesses in visual-motor integration and processing speed compared to the normative sample. Additionally, these children exhibited more mood and behavior symptoms, supporting the need for careful psychological follow-up in this vulnerable population." @default.
• W2896548363 created "2018-10-26" @default.
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• W2896548363 date "2018-01-22" @default.
• W2896548363 modified "2023-09-26" @default.
• W2896548363 title "Abstract WP383: Neuropsychological Outcomes Following Pediatric Cerebral Sinovenous Thrombosis" @default.
• W2896548363 doi "https://doi.org/10.1161/str.49.suppl_1.wp383" @default.
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