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- W2896560219 abstract "Abstract Norepinephrine (NE) and epinephrine (Epi), two key biogenic monoamine neurotransmitters, are involved in a wide range of physiological processes. However, their precise dynamics and regulation remain poorly characterized, in part due to limitations of available techniques for measuring these molecules in vivo . Here, we developed a family of G PC R A ctivation- B ased NE /Epi (GRAB NE ) sensors with a 230% peak ΔF/F 0 response to NE, good photostability, nanomolar-to-micromolar sensitivities, sub-second rapid kinetics, high specificity to NE vs. dopamine. Viral- or transgenic- mediated expression of GRAB NE sensors were able to detect electrical-stimulation evoked NE release in the locus coeruleus (LC) of mouse brain slices, looming-evoked NE release in the midbrain of live zebrafish, as well as optogenetically and behaviorally triggered NE release in the LC and hypothalamus of freely moving mice. Thus, GRAB NE sensors are a robust tool for rapid and specific monitoring of in vivo NE/Epi transmission in both physiological and pathological processes." @default.
- W2896560219 created "2018-10-26" @default.
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- W2896560219 date "2018-10-23" @default.
- W2896560219 modified "2023-09-27" @default.
- W2896560219 title "A genetically encoded fluorescent sensor for rapid and specific in vivo detection of norepinephrine" @default.
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- W2896560219 doi "https://doi.org/10.1101/449546" @default.
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