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- W2896561023 abstract "Harnessing the potential of human stem cells for modeling the physiology and diseases of cortical circuitry requires monitoring cellular dynamics in vivo. We show that human induced pluripotent stem cell (iPSC)-derived cortical neurons transplanted into the adult mouse cortex consistently organized into large (up to ~100 mm3) vascularized neuron-glia territories with complex cytoarchitecture. Longitudinal imaging of >4000 grafted developing human neurons revealed that neuronal arbors refined via branch-specific retraction; human synaptic networks substantially restructured over 4 months, with balanced rates of synapse formation and elimination; and oscillatory population activity mirrored the patterns of fetal neural networks. Lastly, we found increased synaptic stability and reduced oscillations in transplants from two individuals with Down syndrome, demonstrating the potential of in vivo imaging in human tissue grafts for patient-specific modeling of cortical development, physiology, and pathogenesis." @default.
- W2896561023 created "2018-10-26" @default.
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- W2896561023 date "2018-11-16" @default.
- W2896561023 modified "2023-10-08" @default.
- W2896561023 title "In vivo modeling of human neuron dynamics and Down syndrome" @default.
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- W2896561023 doi "https://doi.org/10.1126/science.aau1810" @default.
- W2896561023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6570619" @default.
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