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- W2896561393 abstract "Automated immunoassays can reduce the variability in the analysis of cerebrospinal fluid (CSF) biomarkers and are being implemented widely. However, most of the clinical centers that use CSF biomarkers for diagnosis have determined their cut-off values using non-automated ELISA assays. The aim of this study was to assess the correlation between the INNOTEST ELISA (Fujirebio Europe, Belgium) and the fully automated LUMIPULSE G platform (Fujirebio, Japan) for β-amyloid 1-42 (Aβ1-42) and total Tau (tTau) and to verify how this affects our local cut-off values, in addition to a change in collection and storage tubes. A set of 109 CSF samples from participants of the Sant Pau Initiative on Neurodegeneration cohort (77 controls, 19 subjective cognitive decline, 13 mild cognitive impairment) were analyzed using the INNOTEST β-AMYLOID(1-42) and hTau Ag assays and the Lumipulse G β-Amyloid 1-42 and Total Tau assays on the fully automated LUMIPULSE G platform. All participants underwent a CSF collection according to two different protocols, B and E, using different collection and storage tubes. Samples collected according to protocol B were analyzed on INNOTEST while samples collected according to protocol E were analyzed on LUMIPULSE. To evaluate the effect of the two protocols on the overall correlation between the two platforms, a subset of samples (n=30; protocol B) was analyzed with the two platforms. The mean within-lab variation for Aβ1-42 and tTau was 1.63% and 0.93% for Lumipulse, and 9.35% and 13.2% for INNOTEST, respectively. In samples that have been processed using the same protocol, the correlation between Lumipulse and INNOTEST was high for both Aβ1-42 (R2=0.91; p<0.05) and tTau (R2=0.95; p<0.05). The regression analysis comparing both immunoassays resulted in a slope of 1.74 (intercept -102pg/ml) for Aβ1-42 and 1.01 (intercept 67pg/ml) for tTau. The analysis between different protocols showed that the tube influenced the slopes and intercepts in the method comparison." @default.
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- W2896561393 date "2018-07-01" @default.
- W2896561393 modified "2023-10-08" @default.
- W2896561393 title "P1‐277: CORRELATION BETWEEN INNOTEST® AND THE FULLY AUTOMATED LUMIPULSE® G PLATFORM FOR THE ANALYSIS OF β‐AMYLOID 1‐42 AND TOTAL TAU" @default.
- W2896561393 doi "https://doi.org/10.1016/j.jalz.2018.06.283" @default.
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