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- W2896563358 abstract "Mitochondria are the major cellular energy-producing organelles and intracellular source of reactive oxygen species. These organelles are responsible for driving cell life and death through mitochondrial network structure homeostasis, which is determined by a balance of fission and fusion. Recent advances revealed that a number of components of the fission and fusion machinery, including dynamin-related protein 1 (Drp1), mitofusin1/2 (Mfn1/2) and Optic atrophy 1 (OPA1), that have been implicated in mitochondrial shape changes are indispensible for autophagy, apoptosis and necroptosis. Drp1 is the main regulator of mitochondrial fission and has become a key point of contention. The controversy focuses on whether Drp1 is directly involved in the regulation of cell death and, if involved, whether is it a stimulator or a negative regulator of cell death. Here, we examine the relevance of the homeostasis of the mitochondrial network structure in 3 different types of cell death, including autophagy, apoptosis and necroptosis. Furthermore, a variety of cancers often exhibit a fragmented mitochondrial phenotype. Thus, the fragmented ratio can reflect tumor progression that predicts prognosis and therapeutic response. In addition, we investigate whether the targeting of the mitochondrial fission protein Drp1 could be a novel therapeutic approach." @default.
- W2896563358 created "2018-10-26" @default.
- W2896563358 creator A5002181919 @default.
- W2896563358 creator A5020748598 @default.
- W2896563358 creator A5051769949 @default.
- W2896563358 creator A5075845185 @default.
- W2896563358 creator A5080334653 @default.
- W2896563358 creator A5087504421 @default.
- W2896563358 date "2018-11-16" @default.
- W2896563358 modified "2023-10-17" @default.
- W2896563358 title "Mitochondrial network structure homeostasis and cell death" @default.
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- W2896563358 doi "https://doi.org/10.1111/cas.13830" @default.
- W2896563358 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6272111" @default.