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- W2896566178 abstract "We are using confirmatory factor analysis (CFA) in a Structural Equation Model (SEM) framework to construct a relatively error free, continuous latent measure of dementia severity (i.e., “δ” for “dementia”). The latent variable δ can be “reified” as a composite “d-score” and applied to individuals as an omnibus dementia severity metric. δ’s unique association with dementia, regardless of etiology, has been independently replicated in the National Alzheimer's Coordinating Center (NACC)’s Uniform Dataset (UDS) (N = 26,606) and in well characterized European and Asian samples. Here we describe a new δ homolog, “dT2A”, which will allow for direct replication of δ’s blood-based protein biomarkers between the Texas Alzheimer's Research and Care Consortium (TARCC) (N @ 3,500) and the Alzheimer's Neuroimaging Initiative (ADNI) (N @ 1,750). : δ is an aspect of Spearman's general intelligence factor “g”. Both g and δ are “indifferent” to their indicators. We selected six cognitive indicators which overlap across TARCC's and ADNI's batteries. There was no overlap in measures of Instrumental Activities of Daily Living (IADL). Therefore Lawton's IADL was used as δ’s “target” in TARCC. The Functional Assessment Questionnaire (FAQ) was used in ADNI. Model fit was excellent in both datasets. Factor determinacy was confirmed by Grice's method. dT2A was strongly correlated with Clinical Dementia Rating Scale “sum of boxes” (CDR-SB) in both studies, and dT2A exhibited a high Area Under the Receiver Operating Characteristic Curve (AUC) for the discrimination of Alzheimer's Disease (AD) v. Normal Controls (NC) in both studies. As a demonstration of δ’s indifference to its indicators, we modeled alternative homologs with fewer cognitive indicators. Homologs lacking any combination of Logical Memory II, Boston Naming and /or Animal Naming performed similarly to the full dT2A homolog. This is the twelfth δ homolog validated to date. Regardless of its indicators, δ correlates strongly with CDR-SB and accurately diagnoses dementia, across diagnoses and multiple cohorts. This implicates g as dementia's essential cognitive impairment ." @default.
- W2896566178 created "2018-10-26" @default.
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- W2896566178 date "2018-07-01" @default.
- W2896566178 modified "2023-09-26" @default.
- W2896566178 title "P2‐287: A δ HOMOLOG FOR DEMENTIA CASE FINDING WITH REPLICATION IN ADNI" @default.
- W2896566178 doi "https://doi.org/10.1016/j.jalz.2018.06.976" @default.
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