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• W2896567741 abstract "The global burden of diabetes has drastically increased over the past decades and in 2017 approximately 4 million deaths were caused by diabetes and cardiovascular complications. Diabetic cardiomyopathy is a common complication of diabetes with early manifestations of diastolic dysfunction and left ventricular hypertrophy with subsequent progression to systolic dysfunction and ultimately heart failure. An in vitro model accurately recapitulating key processes of diabetic cardiomyopathy would provide a useful tool for investigations of underlying disease mechanisms to further our understanding of the disease and thereby potentially advance treatment strategies for patients. With their proliferative capacity and differentiation potential, human induced pluripotent stem cells (iPSCs) represent an appealing cell source for such a model system and cardiomyocytes derived from induced pluripotent stem cells have been used to establish other cardiovascular related disease models. Here we review recently made advances and discuss challenges still to be overcome with regard to diabetic cardiomyopathy models, with a special focus on iPSC-based systems. Recent publications as well as preliminary data presented here demonstrate the feasibility of generating cardiomyocytes with a diabetic phenotype, displaying insulin resistance, impaired calcium handling and hypertrophy. However, capturing the full metabolic- and functional phenotype of the diabetic cardiomyocyte remains to be accomplished." @default.
• W2896567741 created "2018-10-26" @default.
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• W2896567741 creator A5051673975 @default.
• W2896567741 date "2018-10-20" @default.
• W2896567741 modified "2023-10-16" @default.
• W2896567741 title "Diabetic Cardiomyopathy Modelling Using Induced Pluripotent Stem Cell Derived Cardiomyocytes: Recent Advances and Emerging Models" @default.
• W2896567741 cites W1513319197 @default.
• W2896567741 cites W1519485868 @default.
• W2896567741 cites W1661548638 @default.
• W2896567741 cites W1747672433 @default.
• W2896567741 cites W1887831497 @default.
• W2896567741 cites W1964434851 @default.
• W2896567741 cites W1968572097 @default.
• W2896567741 cites W1972142752 @default.
• W2896567741 cites W1986276307 @default.
• W2896567741 cites W1990864926 @default.
• W2896567741 cites W1995448106 @default.
• W2896567741 cites W1995508726 @default.
• W2896567741 cites W1999118044 @default.
• W2896567741 cites W1999736924 @default.
• W2896567741 cites W2006499762 @default.
• W2896567741 cites W2014051267 @default.
• W2896567741 cites W2017133833 @default.
• W2896567741 cites W2022229270 @default.
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• W2896567741 cites W2048243122 @default.
• W2896567741 cites W2056133957 @default.
• W2896567741 cites W2059743234 @default.
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• W2896567741 cites W2118555195 @default.
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• W2896567741 cites W2269640239 @default.
• W2896567741 cites W2273304042 @default.
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• W2896567741 cites W2410730629 @default.
• W2896567741 cites W2411240035 @default.
• W2896567741 cites W2510668402 @default.
• W2896567741 cites W2586243829 @default.
• W2896567741 cites W2591558322 @default.
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• W2896567741 cites W2601330602 @default.
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• W2896567741 doi "https://doi.org/10.1007/s12015-018-9858-1" @default.
• W2896567741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6513824" @default.
• W2896567741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30343468" @default.
• W2896567741 hasPublicationYear "2018" @default.
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