Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896570919> ?p ?o ?g. }
- W2896570919 endingPage "432" @default.
- W2896570919 startingPage "423" @default.
- W2896570919 abstract "Vancomycin empirical dosing studies in thermally injured patients have netted low successful target attainment and most excluded renal dysfunction, limiting applicability. In a previous study, the authors performed a retrospective analysis of 124 patients’ measured pharmacokinetic parameters to calculate optimal dose and interval for intermittent infusion regimens and find predictors of clearance and total daily dose. The objective of this study was to improve the accuracy of attaining goal therapeutic targets with initial vancomycin regimens in patients with thermal injury through retrospective modeling. In this phase 2 study, variables collected and calculated regimens in phase 1 were utilized to try and create an improved empiric vancomycin dosing algorithm in patients with thermal injury. Logistic regression was utilized to determine best predictors of dosing vancomycin every 6 and 8 h. The strongest models were built as individual algorithms and tested for accuracy of target attainment. Each algorithm produced a regimen for each patient that was then tested utilizing each patient’s actual measured pharmacokinetic parameters. Univariable logistic regression of 41 variables identified 27 and 23 to be predictive of dosing every 8 or 6 h, respectively. The most predictive multivariable model for dosing every 8 h consisted of creatinine clearance (CrCl) ≥ 80 ml/min, Acute Kidney Injury Network classification <1, and total body surface area burned ≥ 10 percent. For dosing every 6 h, CrCl ≥ 80 ml/min, age ≤ 40 years old, days since injury ≤ 6, and serum creatinine (SCr) ≤ 0.8 were most predictive. Based on the top 5 multivariable models for each dosing interval, 7 algorithms were built to produce recommended regimens. The highest performing algorithm resulted in trough concentrations of <10 mg/L (23%), 10–20 mg/L (65%), 15–20 mg/L (26%), and >20 mg/L (11%); area under the concentration curve (AUC) > 400 mg hr/L (83%); and AUC > 400 mg hr/L without having a trough >20 mg/L (72%). The algorithm that resulted in the highest target attainment without overdosing recommended 15 mg/kg dosed every 24 h for CrCl ≥ 30, every 12 h for CrCl 31–79, every 8 h for patients with CrCl ≥ 80 ml/min, and every 6 h only if the patient with a CrCl ≥ 80 ml/min is also ≤ 40 years old and has a SCr ≤ 0.8. Caution is warranted for groups underrepresented in this study, such as those with very low CrCl, a low BMI, or receiving renal replacement therapy. This algorithm should be validated in other centers for patients with thermal injuries." @default.
- W2896570919 created "2018-10-26" @default.
- W2896570919 creator A5006085236 @default.
- W2896570919 creator A5031302291 @default.
- W2896570919 creator A5053340526 @default.
- W2896570919 creator A5071663783 @default.
- W2896570919 creator A5078909705 @default.
- W2896570919 creator A5088069091 @default.
- W2896570919 date "2019-03-01" @default.
- W2896570919 modified "2023-10-15" @default.
- W2896570919 title "Optimization of an empiric vancomycin dosing algorithm for improved target concentration attainment in patients with thermal injury" @default.
- W2896570919 cites W1550111394 @default.
- W2896570919 cites W1966712641 @default.
- W2896570919 cites W1971251009 @default.
- W2896570919 cites W1972470346 @default.
- W2896570919 cites W1975942389 @default.
- W2896570919 cites W1982348201 @default.
- W2896570919 cites W1982633331 @default.
- W2896570919 cites W1985643390 @default.
- W2896570919 cites W2011312924 @default.
- W2896570919 cites W2013678400 @default.
- W2896570919 cites W2013852596 @default.
- W2896570919 cites W2018246383 @default.
- W2896570919 cites W2027799176 @default.
- W2896570919 cites W2032381943 @default.
- W2896570919 cites W2032488998 @default.
- W2896570919 cites W2066268964 @default.
- W2896570919 cites W2071828147 @default.
- W2896570919 cites W2076977991 @default.
- W2896570919 cites W2086386583 @default.
- W2896570919 cites W2089290463 @default.
- W2896570919 cites W2093989241 @default.
- W2896570919 cites W2110588410 @default.
- W2896570919 cites W2133120422 @default.
- W2896570919 cites W2138507882 @default.
- W2896570919 cites W2152771638 @default.
- W2896570919 cites W2158657903 @default.
- W2896570919 cites W2160288749 @default.
- W2896570919 cites W2166799273 @default.
- W2896570919 cites W2169405810 @default.
- W2896570919 cites W2433440740 @default.
- W2896570919 cites W2553498384 @default.
- W2896570919 cites W2606826360 @default.
- W2896570919 cites W2766313666 @default.
- W2896570919 doi "https://doi.org/10.1016/j.burns.2018.09.025" @default.
- W2896570919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30340863" @default.
- W2896570919 hasPublicationYear "2019" @default.
- W2896570919 type Work @default.
- W2896570919 sameAs 2896570919 @default.
- W2896570919 citedByCount "7" @default.
- W2896570919 countsByYear W28965709192019 @default.
- W2896570919 countsByYear W28965709192021 @default.
- W2896570919 countsByYear W28965709192022 @default.
- W2896570919 countsByYear W28965709192023 @default.
- W2896570919 crossrefType "journal-article" @default.
- W2896570919 hasAuthorship W2896570919A5006085236 @default.
- W2896570919 hasAuthorship W2896570919A5031302291 @default.
- W2896570919 hasAuthorship W2896570919A5053340526 @default.
- W2896570919 hasAuthorship W2896570919A5071663783 @default.
- W2896570919 hasAuthorship W2896570919A5078909705 @default.
- W2896570919 hasAuthorship W2896570919A5088069091 @default.
- W2896570919 hasConcept C112705442 @default.
- W2896570919 hasConcept C11413529 @default.
- W2896570919 hasConcept C126322002 @default.
- W2896570919 hasConcept C151956035 @default.
- W2896570919 hasConcept C159641895 @default.
- W2896570919 hasConcept C167135981 @default.
- W2896570919 hasConcept C2777288759 @default.
- W2896570919 hasConcept C2778980435 @default.
- W2896570919 hasConcept C2779489039 @default.
- W2896570919 hasConcept C2780306776 @default.
- W2896570919 hasConcept C2780472472 @default.
- W2896570919 hasConcept C41008148 @default.
- W2896570919 hasConcept C44249647 @default.
- W2896570919 hasConcept C523546767 @default.
- W2896570919 hasConcept C54355233 @default.
- W2896570919 hasConcept C71924100 @default.
- W2896570919 hasConcept C86803240 @default.
- W2896570919 hasConceptScore W2896570919C112705442 @default.
- W2896570919 hasConceptScore W2896570919C11413529 @default.
- W2896570919 hasConceptScore W2896570919C126322002 @default.
- W2896570919 hasConceptScore W2896570919C151956035 @default.
- W2896570919 hasConceptScore W2896570919C159641895 @default.
- W2896570919 hasConceptScore W2896570919C167135981 @default.
- W2896570919 hasConceptScore W2896570919C2777288759 @default.
- W2896570919 hasConceptScore W2896570919C2778980435 @default.
- W2896570919 hasConceptScore W2896570919C2779489039 @default.
- W2896570919 hasConceptScore W2896570919C2780306776 @default.
- W2896570919 hasConceptScore W2896570919C2780472472 @default.
- W2896570919 hasConceptScore W2896570919C41008148 @default.
- W2896570919 hasConceptScore W2896570919C44249647 @default.
- W2896570919 hasConceptScore W2896570919C523546767 @default.
- W2896570919 hasConceptScore W2896570919C54355233 @default.
- W2896570919 hasConceptScore W2896570919C71924100 @default.
- W2896570919 hasConceptScore W2896570919C86803240 @default.
- W2896570919 hasIssue "2" @default.
- W2896570919 hasLocation W28965709191 @default.
- W2896570919 hasLocation W28965709192 @default.