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• W2896573739 abstract "Objective To investigate the effects of resistance and aerobic training on the content of fibronectin in skeletal muscle extracellular matrix and satellite cell in 9-month-old BALB/c mice, and then explore the effect of fibronectin content change on satellite cell and its intrinsic mechanism, which will provide a new research perspective and theoretical evidence for delaying sarcopenia.&#x0D; Methods 27 one-month-old BALB / c mice of SPF grade were purchased and fed for natural aging. At 9 months of age, the mice were divided into three groups randomly. Group R was resistance exercise training group (n=9), group A was aerobic exercise training group (n=9), and group C was control group (n=9). The load ladder model for resistance training in group R, the pyramid training program for 9 week training, 5 sets of load ladder training every time. 2 min for rest between sets, 1 min for rest between repetitions, 3 times a week. The treadmill training for aerobic training in group A for 9 weeks, the speed of 0.8km/h, 40min every time, 3 times a week. There is no training in group C. During the training, mouse grip strength was tested by the BIOSEB grip instrument once a week. After exercise intervention, the blood of mice was taken from the eyeball, and the gastrocnemius muscles were removed and placed in -80℃ temperature refrigerator to be freezed for tested . Immunofluorescence was used to detect FN and Pax7; The Real-time PCR was used to detect mRNA of FN, Sdc4, Fzd7, Wnt7a, c-Jun, Pax7; Western Blotting was used to detect the FN, sdc4, Fzd7, Wnt7a, c-Jun, p-c-Jun, Pax7 protein content.&#x0D; Results (1) Body weight, grip strength and skeletal muscle mass of mice: The body weight of group C and group R were significantly decreased after 9 weeks to compared with group A (P <0.05; P <0.05). The grip strength of group R and A was significantly increased in the ninth week to compared with group C, (P <0.01; P <0.05); The grip strength of group R and A in the ninth week were significantly higher than that in the first week (P <0.01; P <0.01)；&#x0D; (2) FN in skeletal muscle extracellular matrix and it’s receptor Sdc4: The integrated optical density (IOD) of FN in group R was higher than that in group C and group A, but there was no significant difference among the three groups. The FN mRNA in group R was significantly increased to compared with group A (P<0.05). The FN protein content in group R was significantly increased to compared with group C and group A (P <0.01; P <0.01). There was no significant difference in the expression of Sdc4 mRNA in gastrocnemius muscle among the three groups. Compared with group C, the Sdc4 protein content was significantly down-regulated in both group R and group A (P<0.01; P<0.05).&#x0D; (3) Wnt7a/PCP signaling pathway: The Wnt7a mRNA and Wnt7a protein content in the gastrocnemius muscle of group R were significantly increased to compared with group C (P<0.05; P<0.01)). Compared with group A, Wnt7a protein content in group R was also significantly increased (P<0.05). There was no significant difference in Fzd7 mRNA in gastrocnemius muscle among the three groups; but the Fzd7 protein content in group R was significantly increased to compared with group A (P<0.05). The c-Jun mRNA in group R was significantly increased to compared with group C and A (P<0.05; P< 0.05). The content of c-Jun protein in group R was significantly increased to compared with group C and group A (P<0.01; P<0.01). The content of p-c-Jun protein in group R was significantly increased to compared with group C (P<0.05). &#x0D; (4) Pax7 : The number of Pax7 positive cells in group R was higher than that in group C and group A, but there was no significant difference among the three groups. Pax7 mRNA in group R and group A were significantly lower than that in group C (P<0.05; P<0.01), but Pax7 protein content in group R was significantly higher than group C and group A (P <0.05; P <0.05)&#x0D; Conclusions (1) Exercise can improve muscle strength of aging mice.&#x0D; (2) Resistance training can promote FN in skeletal muscle extracellular matrix and improve skeletal muscle extracellular matrix components of aging mice.&#x0D; (3) Resistance exercise training can promote Pax7 expression through the increase of FN and up-regulation of Wnt7a / PCP signaling pathway, thus make it possible for satellite cell proliferation." @default.
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• W2896573739 date "2018-10-04" @default.
• W2896573739 modified "2023-10-14" @default.
• W2896573739 title "PO-184 Effects of resistance training and aerobic training on Fibronectin of Skeletal Muscle Extracellular Matrix and Satellite Cell in Aging Mice" @default.
• W2896573739 doi "https://doi.org/10.14428/ebr.v1i4.12773" @default.
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