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- W2896575237 abstract "Neuropsychological evaluation often plays a central role in dementia diagnosis. Specific cognitive phenotypes (e.g., amnestic vs. non-amnestic memory profiles) are used to differentiate Alzheimer's disease from other neurodegenerative conditions. The Imaging in Dementia Evidence for Amyloid Scanning (IDEAS) trial offers a unique opportunity to examine patients’ neuropsychological data in relationship to amyloid status. Patients with atypical mild cognitive impairment (MCI) or dementia diagnosis completed neuropsychological evaluation and amyloid-PET imaging, either through IDEAS (n=44) or independently of this trial (n=4). Demographic variables, cognitive screening results, neuropsychological data, and pre- and post-PET diagnoses were manually extracted from the electronic medical record (EMR). Neuropsychological data was characterized by two neuropsychologists with subspecialty training in neurodegenerative disease. Amyloid status was determined by consensus between a radiologist and behavioral neurologist. A total of 48 patients (mean age 71.1±8.2, 53.3% female) completed amyloid PET imaging with an average MOCA score of 19.6± 6.3. Neuropsychological testing yielded an amnestic memory profile in 39.6% of subjects. However, 58.3% of individuals enrolled in the study were found to be amyloid positive. Notably, non-amnestic memory profiles were observed in 33.3% of amyloid positive subjects ultimately diagnosed with AD and in 71.4% of amyloid positive individuals who received a diagnosis of MCI due to AD. Amyloid positive subjects diagnosed with an atypical presentation of AD (posterior cortical atrophy, progressive primary aphasia, or corticobasal degeneration), displayed non-amnestic memory profiles in 33.3% of cases. Findings suggest a significant percentage of amyloid positive patients do not show the hallmark signs of an amnestic memory disturbance traditionally associated with AD. Amyloid imaging has the potential to contribute to the differential diagnosis of neurodegenerative disease." @default.
- W2896575237 created "2018-10-26" @default.
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- W2896575237 date "2018-07-01" @default.
- W2896575237 modified "2023-10-16" @default.
- W2896575237 title "P3‐480: AMYLOID PET IMAGING AND NEUROPSYCHOLOGICAL PHENOTYPES IN ALZHEIMER'S AND NON‐ALZHEIMER'S DEMENTIAS" @default.
- W2896575237 doi "https://doi.org/10.1016/j.jalz.2018.06.1844" @default.
- W2896575237 hasPublicationYear "2018" @default.
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