FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896580959> ?p ?o ?g. }

• W2896580959 abstract "A key part of the Risk Assessment of excipients is to understand how raw material variability could (or does) contribute to differences in performance of the drug product. Here we demonstrate an approach which achieves the necessary understanding for a complex, functional, excipient. Multivariate analysis (MVA) of the certificates of analysis of an ethylcellulose aqueous dispersion (Surelease) formulation revealed low overall variability of the properties of the systems. Review of the scores plot to highlight batches manufactured using the same ethylcellulose raw material in the formulation, indicated that these batches tend to be more closely related than other randomly selected batches. This variability could result in potential differences in the quality of drug product lots made from these batches. Manufacture of a model drug product from Surelease batches coated using different lots of starting material revealed small differences in the release of a model drug, which could be detected by certain model dependent dissolution modeling techniques, but they were not observed when using model-independent techniques. This illustrates that the techniques are suitable for detecting and understanding excipient variability, but that, in this case, the product was still robust." @default.
• W2896580959 created "2018-10-26" @default.
• W2896580959 creator A5019267444 @default.
• W2896580959 creator A5023054903 @default.
• W2896580959 creator A5026372655 @default.
• W2896580959 creator A5028680897 @default.
• W2896580959 creator A5063693822 @default.
• W2896580959 creator A5066887106 @default.
• W2896580959 creator A5081874228 @default.
• W2896580959 creator A5085765854 @default.
• W2896580959 date "2018-11-14" @default.
• W2896580959 modified "2023-10-17" @default.
• W2896580959 title "Multivariate analysis as a method to understand variability in a complex excipient, and its contribution to formulation performance" @default.
• W2896580959 cites W1419666075 @default.
• W2896580959 cites W145916831 @default.
• W2896580959 cites W1513206599 @default.
• W2896580959 cites W1994624055 @default.
• W2896580959 cites W1998095036 @default.
• W2896580959 cites W1998871511 @default.
• W2896580959 cites W2009242118 @default.
• W2896580959 cites W2017781159 @default.
• W2896580959 cites W2019914113 @default.
• W2896580959 cites W2021145686 @default.
• W2896580959 cites W2041515373 @default.
• W2896580959 cites W2068280589 @default.
• W2896580959 cites W2083493632 @default.
• W2896580959 cites W2113237472 @default.
• W2896580959 cites W2115439624 @default.
• W2896580959 cites W2168346825 @default.
• W2896580959 cites W2171653766 @default.
• W2896580959 cites W2179773495 @default.
• W2896580959 cites W2227221655 @default.
• W2896580959 cites W2256574367 @default.
• W2896580959 cites W2332292710 @default.
• W2896580959 cites W2339207792 @default.
• W2896580959 cites W244127115 @default.
• W2896580959 cites W2551703891 @default.
• W2896580959 cites W2553624597 @default.
• W2896580959 cites W2561261022 @default.
• W2896580959 cites W2568134070 @default.
• W2896580959 cites W2616873797 @default.
• W2896580959 cites W2621086753 @default.
• W2896580959 cites W2754896635 @default.
• W2896580959 cites W2800151631 @default.
• W2896580959 cites W2800236607 @default.
• W2896580959 cites W2802346012 @default.
• W2896580959 cites W49511044 @default.
• W2896580959 doi "https://doi.org/10.1080/10837450.2018.1534862" @default.
• W2896580959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30303433" @default.
• W2896580959 hasPublicationYear "2018" @default.
• W2896580959 type Work @default.
• W2896580959 sameAs 2896580959 @default.
• W2896580959 citedByCount "2" @default.
• W2896580959 countsByYear W28965809592023 @default.
• W2896580959 crossrefType "journal-article" @default.
• W2896580959 hasAuthorship W2896580959A5019267444 @default.
• W2896580959 hasAuthorship W2896580959A5023054903 @default.
• W2896580959 hasAuthorship W2896580959A5026372655 @default.
• W2896580959 hasAuthorship W2896580959A5028680897 @default.
• W2896580959 hasAuthorship W2896580959A5063693822 @default.
• W2896580959 hasAuthorship W2896580959A5066887106 @default.
• W2896580959 hasAuthorship W2896580959A5081874228 @default.
• W2896580959 hasAuthorship W2896580959A5085765854 @default.
• W2896580959 hasBestOaLocation W28965809592 @default.
• W2896580959 hasConcept C105795698 @default.
• W2896580959 hasConcept C119857082 @default.
• W2896580959 hasConcept C127413603 @default.
• W2896580959 hasConcept C161584116 @default.
• W2896580959 hasConcept C178790620 @default.
• W2896580959 hasConcept C183696295 @default.
• W2896580959 hasConcept C185592680 @default.
• W2896580959 hasConcept C206139338 @default.
• W2896580959 hasConcept C21880701 @default.
• W2896580959 hasConcept C2777239854 @default.
• W2896580959 hasConcept C33923547 @default.
• W2896580959 hasConcept C41008148 @default.
• W2896580959 hasConcept C43617362 @default.
• W2896580959 hasConceptScore W2896580959C105795698 @default.
• W2896580959 hasConceptScore W2896580959C119857082 @default.
• W2896580959 hasConceptScore W2896580959C127413603 @default.
• W2896580959 hasConceptScore W2896580959C161584116 @default.
• W2896580959 hasConceptScore W2896580959C178790620 @default.
• W2896580959 hasConceptScore W2896580959C183696295 @default.
• W2896580959 hasConceptScore W2896580959C185592680 @default.
• W2896580959 hasConceptScore W2896580959C206139338 @default.
• W2896580959 hasConceptScore W2896580959C21880701 @default.
• W2896580959 hasConceptScore W2896580959C2777239854 @default.
• W2896580959 hasConceptScore W2896580959C33923547 @default.
• W2896580959 hasConceptScore W2896580959C41008148 @default.
• W2896580959 hasConceptScore W2896580959C43617362 @default.
• W2896580959 hasLocation W28965809591 @default.
• W2896580959 hasLocation W28965809592 @default.
• W2896580959 hasLocation W28965809593 @default.
• W2896580959 hasOpenAccess W2896580959 @default.
• W2896580959 hasPrimaryLocation W28965809591 @default.
• W2896580959 hasRelatedWork W1582393198 @default.
• W2896580959 hasRelatedWork W2167226206 @default.
• W2896580959 hasRelatedWork W2351745043 @default.
• W2896580959 hasRelatedWork W2477285746 @default.
• W2896580959 hasRelatedWork W2481133392 @default.

• next