Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896582396> ?p ?o ?g. }
- W2896582396 endingPage "145" @default.
- W2896582396 startingPage "145" @default.
- W2896582396 abstract "Peripheral artery disease (PAD) is an atherosclerotic disease characterized by a narrowing of the arteries in the lower extremities. Disease manifestations are the result of more than just reduced blood flow, and include endothelial dysfunction, arterial stiffness, and inflammation. Growing evidence suggests that these factors lead to functional impairment and decline in PAD patients. Oxidative stress also plays an important role in the disease, and a growing amount of data suggest a link between arterial dysfunction and oxidative stress. In this review, we present the current evidence for the involvement of endothelial dysfunction, arterial stiffness, and inflammation in the pathophysiology of PAD. We also discuss the links between these factors and oxidative stress, with a focus on nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2)-derived reactive oxygen species (ROS) and decreased nitric oxide (NO) bioavailability. Finally, the potential therapeutic role of NOX2 antioxidants for improving arterial function and functional status in PAD patients is explored." @default.
- W2896582396 created "2018-10-26" @default.
- W2896582396 creator A5009222089 @default.
- W2896582396 creator A5035915925 @default.
- W2896582396 creator A5043888360 @default.
- W2896582396 creator A5045691393 @default.
- W2896582396 creator A5049835071 @default.
- W2896582396 creator A5068813735 @default.
- W2896582396 creator A5082319313 @default.
- W2896582396 creator A5083848076 @default.
- W2896582396 creator A5084905749 @default.
- W2896582396 creator A5085858872 @default.
- W2896582396 date "2018-10-19" @default.
- W2896582396 modified "2023-09-26" @default.
- W2896582396 title "Oxidative Stress and Arterial Dysfunction in Peripheral Artery Disease" @default.
- W2896582396 cites W122349615 @default.
- W2896582396 cites W1560709565 @default.
- W2896582396 cites W1905740399 @default.
- W2896582396 cites W1923914039 @default.
- W2896582396 cites W1948854550 @default.
- W2896582396 cites W1965568731 @default.
- W2896582396 cites W1968302053 @default.
- W2896582396 cites W1969643223 @default.
- W2896582396 cites W1972621186 @default.
- W2896582396 cites W1973978803 @default.
- W2896582396 cites W1974997758 @default.
- W2896582396 cites W1975182195 @default.
- W2896582396 cites W1976624449 @default.
- W2896582396 cites W1982434264 @default.
- W2896582396 cites W1985326793 @default.
- W2896582396 cites W1985410641 @default.
- W2896582396 cites W1987360628 @default.
- W2896582396 cites W1988097865 @default.
- W2896582396 cites W1990481028 @default.
- W2896582396 cites W1993060519 @default.
- W2896582396 cites W1994138576 @default.
- W2896582396 cites W1995568914 @default.
- W2896582396 cites W1995605639 @default.
- W2896582396 cites W1996357157 @default.
- W2896582396 cites W1997448590 @default.
- W2896582396 cites W1999033829 @default.
- W2896582396 cites W2002081634 @default.
- W2896582396 cites W2005040847 @default.
- W2896582396 cites W2012840031 @default.
- W2896582396 cites W2013521697 @default.
- W2896582396 cites W2016913364 @default.
- W2896582396 cites W2019558661 @default.
- W2896582396 cites W2019734515 @default.
- W2896582396 cites W2020245957 @default.
- W2896582396 cites W2023536393 @default.
- W2896582396 cites W2029198912 @default.
- W2896582396 cites W2034942998 @default.
- W2896582396 cites W2043108620 @default.
- W2896582396 cites W2045946456 @default.
- W2896582396 cites W2046933813 @default.
- W2896582396 cites W2049043600 @default.
- W2896582396 cites W2049978396 @default.
- W2896582396 cites W2056816257 @default.
- W2896582396 cites W2059947958 @default.
- W2896582396 cites W2061005453 @default.
- W2896582396 cites W2063681611 @default.
- W2896582396 cites W2067095896 @default.
- W2896582396 cites W2069306894 @default.
- W2896582396 cites W2069490874 @default.
- W2896582396 cites W2070875954 @default.
- W2896582396 cites W2080265235 @default.
- W2896582396 cites W2084120431 @default.
- W2896582396 cites W2084141237 @default.
- W2896582396 cites W2085137779 @default.
- W2896582396 cites W2089538662 @default.
- W2896582396 cites W2093181834 @default.
- W2896582396 cites W2095592188 @default.
- W2896582396 cites W2096647847 @default.
- W2896582396 cites W2096869450 @default.
- W2896582396 cites W2097719554 @default.
- W2896582396 cites W2098492935 @default.
- W2896582396 cites W2099809942 @default.
- W2896582396 cites W2105210238 @default.
- W2896582396 cites W2107509703 @default.
- W2896582396 cites W2107683340 @default.
- W2896582396 cites W2107714010 @default.
- W2896582396 cites W2107948591 @default.
- W2896582396 cites W2113320044 @default.
- W2896582396 cites W2114828612 @default.
- W2896582396 cites W2118084768 @default.
- W2896582396 cites W2118250164 @default.
- W2896582396 cites W2120832973 @default.
- W2896582396 cites W2123603955 @default.
- W2896582396 cites W2127773685 @default.
- W2896582396 cites W2127990403 @default.
- W2896582396 cites W2131048176 @default.
- W2896582396 cites W2131060612 @default.
- W2896582396 cites W2132644046 @default.
- W2896582396 cites W2132768366 @default.
- W2896582396 cites W2138209376 @default.
- W2896582396 cites W2138223428 @default.
- W2896582396 cites W2141665762 @default.
- W2896582396 cites W2148090649 @default.