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• W2896586246 endingPage "52" @default.
• W2896586246 startingPage "37" @default.
• W2896586246 abstract "Summary Group 2 innate lymphoid cells ( ILC 2s) play critical roles in the induction of type 2 inflammation, response to parasite infection, metabolic homeostasis, and tissue repair. These multifunctional roles of ILC 2s are tightly controlled by complex regulatory systems in the local microenvironment, the disruption of which may cause various health problems. This review summarizes up‐to‐date knowledge regarding positive and negative regulators for ILC 2s based on their function and signaling pathways, including activating cytokines ( IL ‐33, IL ‐25; MAPK , NF ‐κB pathways), co‐stimulatory cytokines ( IL ‐2, IL ‐7, IL ‐9, TSLP ; STAT 5, IL ‐4; STAT 6, TNF superfamily; MAPK , NF ‐κB pathways), suppressive cytokines (type1 IFN s, IFN ‐γ, IL ‐27; STAT 1, IL ‐10, TGF ‐β), transdifferentiation cytokines ( IL ‐12; STAT 4, IL ‐1β, IL ‐18), lipid mediators ( LTC 4, LTD 4, LTE 4, PGD 2; Ca 2+ ‐ NFAT pathways, PGE 2, PGI 2; AC / cAMP / PKA pathways, LXA 4, LTB 4), neuropeptides ( NMU ; Ca 2+ ‐ NFAT , MAPK pathways, VIP , CGRP , catecholamine, acetylcholine), sex hormones (androgen, estrogen), nutrients (butyrate; HDAC inhibitors, vitamins), and cell‐to‐cell interactions ( ICOSL ‐ ICOS ; STAT 5, B7‐H6‐ NK p30, E‐cadherin‐ KLRG 1). This comprehensive review affords a better understanding of the regulatory network system for ILC 2s, providing impetus to develop new treatment strategies for ILC 2‐related health problems." @default.
• W2896586246 created "2018-10-26" @default.
• W2896586246 creator A5055091682 @default.
• W2896586246 creator A5077365104 @default.
• W2896586246 creator A5084178900 @default.
• W2896586246 date "2018-10-07" @default.
• W2896586246 modified "2023-10-16" @default.
• W2896586246 title "The group 2 innate lymphoid cell (<scp>ILC</scp>2) regulatory network and its underlying mechanisms" @default.
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