Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896590480> ?p ?o ?g. }
- W2896590480 endingPage "281" @default.
- W2896590480 startingPage "259" @default.
- W2896590480 abstract "The human Far Upstream Element (FUSE) Binding Protein 1 (FUBP1) is a multifunctional DNA- and RNA-binding protein involved in diverse cellular processes. FUBP1 is a master regulator of transcription, translation, and RNA splicing. FUBP1 has been identified as a potent pro-proliferative and anti-apoptotic factor by modulation of complex networks. FUBP1 is also described either as an oncoprotein or a tumor suppressor. Especially, FUBP1 overexpression is observed in a growing number of cancer and leads to a deregulation of targets that includes the fine-tuned MYC oncogene. Moreover, recent loss-of-function analyses of FUBP1 establish its essential functions in hematopoietic stem cell maintenance and survival. Therefore, FUBP1 appears as an emerging suspect in hematologic disorders in addition to solid tumors. The scope of the present review is to describe the advances in our understanding of the molecular basis of FUBP1 functions in normal cells and carcinogenesis. We also delineate the recent progresses in the understanding of the master role of FUBP1 in normal and pathological hematopoiesis. We conclude that FUBP1 is not only worth studying biologically but is also of clinical relevance through its pivotal role in regulating multiple cellular processes and its involvement in oncogenesis." @default.
- W2896590480 created "2018-10-26" @default.
- W2896590480 creator A5035201741 @default.
- W2896590480 creator A5069508829 @default.
- W2896590480 date "2018-10-20" @default.
- W2896590480 modified "2023-10-14" @default.
- W2896590480 title "The master regulator FUBP1: its emerging role in normal cell function and malignant development" @default.
- W2896590480 cites W1187071477 @default.
- W2896590480 cites W1506088472 @default.
- W2896590480 cites W1552274890 @default.
- W2896590480 cites W1561524145 @default.
- W2896590480 cites W1598513412 @default.
- W2896590480 cites W1790543114 @default.
- W2896590480 cites W1812256879 @default.
- W2896590480 cites W1871743825 @default.
- W2896590480 cites W1949929538 @default.
- W2896590480 cites W1963868441 @default.
- W2896590480 cites W1964079962 @default.
- W2896590480 cites W1964891290 @default.
- W2896590480 cites W1967358345 @default.
- W2896590480 cites W1973165481 @default.
- W2896590480 cites W1974580999 @default.
- W2896590480 cites W1974815839 @default.
- W2896590480 cites W1974943984 @default.
- W2896590480 cites W1976415203 @default.
- W2896590480 cites W1979061637 @default.
- W2896590480 cites W1979607371 @default.
- W2896590480 cites W1986092833 @default.
- W2896590480 cites W1987002611 @default.
- W2896590480 cites W1988339551 @default.
- W2896590480 cites W1988995126 @default.
- W2896590480 cites W1989023011 @default.
- W2896590480 cites W1991419585 @default.
- W2896590480 cites W1991870868 @default.
- W2896590480 cites W1993636331 @default.
- W2896590480 cites W1995692965 @default.
- W2896590480 cites W1996487270 @default.
- W2896590480 cites W1997058261 @default.
- W2896590480 cites W1997773453 @default.
- W2896590480 cites W2002900988 @default.
- W2896590480 cites W2006770045 @default.
- W2896590480 cites W2011920499 @default.
- W2896590480 cites W2013128876 @default.
- W2896590480 cites W2015050458 @default.
- W2896590480 cites W2016763316 @default.
- W2896590480 cites W2016776106 @default.
- W2896590480 cites W2017306557 @default.
- W2896590480 cites W2017817862 @default.
- W2896590480 cites W2018494368 @default.
- W2896590480 cites W2020352533 @default.
- W2896590480 cites W2021536610 @default.
- W2896590480 cites W2021630037 @default.
- W2896590480 cites W2022064821 @default.
- W2896590480 cites W2022801726 @default.
- W2896590480 cites W2026273737 @default.
- W2896590480 cites W2028056951 @default.
- W2896590480 cites W2028102548 @default.
- W2896590480 cites W2029688300 @default.
- W2896590480 cites W2030693010 @default.
- W2896590480 cites W2031183821 @default.
- W2896590480 cites W2031570299 @default.
- W2896590480 cites W2032530241 @default.
- W2896590480 cites W2036109241 @default.
- W2896590480 cites W2038487518 @default.
- W2896590480 cites W2038630108 @default.
- W2896590480 cites W2040310860 @default.
- W2896590480 cites W2040685897 @default.
- W2896590480 cites W2043274355 @default.
- W2896590480 cites W2043398720 @default.
- W2896590480 cites W2045807926 @default.
- W2896590480 cites W2048249977 @default.
- W2896590480 cites W2048651813 @default.
- W2896590480 cites W2053690380 @default.
- W2896590480 cites W2054322190 @default.
- W2896590480 cites W2058947076 @default.
- W2896590480 cites W2061424947 @default.
- W2896590480 cites W2065068903 @default.
- W2896590480 cites W2066277278 @default.
- W2896590480 cites W2067275681 @default.
- W2896590480 cites W2068419083 @default.
- W2896590480 cites W2068526813 @default.
- W2896590480 cites W2068529673 @default.
- W2896590480 cites W2068881880 @default.
- W2896590480 cites W2071753279 @default.
- W2896590480 cites W2071846761 @default.
- W2896590480 cites W2074302728 @default.
- W2896590480 cites W2082230452 @default.
- W2896590480 cites W2084268608 @default.
- W2896590480 cites W2087819495 @default.
- W2896590480 cites W2090430685 @default.
- W2896590480 cites W2091222325 @default.
- W2896590480 cites W2092078270 @default.
- W2896590480 cites W2092675732 @default.
- W2896590480 cites W2096549757 @default.
- W2896590480 cites W2097494822 @default.
- W2896590480 cites W2097605343 @default.
- W2896590480 cites W2099058826 @default.
- W2896590480 cites W2100365251 @default.