FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896591601> ?p ?o ?g. }

• W2896591601 endingPage "581" @default.
• W2896591601 startingPage "573" @default.
• W2896591601 abstract "Biofilm formation is a relevant risk factor for mortality in candidemia. Data about serum-based susceptibility testing against Candida biofilms are scant; therefore, the activity of fluconazole, amphotericin B, caspofungin and micafungin was determined against Candida albicans and C. parapsilosis biofilms with or without 50% human serum using XTT-based assays. Serum caused a remarkable adverse effect regarding biofilm structure for both species. Additionally, the ratio of nonviable cells increased for C. parapsilosis biofilms, as confirmed by fluorescent microscopy and flow cytometry. Despite impaired biofilm development, traditionally biofilm-active antifungals, surprisingly, showed decreased activity against C. albicans biofilms in serum at concentrations ranging from 0.5 to 1 mg/l and from 0.015 to 1 mg/l for amphotericin B and echinocandins, respectively (P < .01–.05). However, C. parapsilosis showed higher susceptibility to these antifungals due to reduced biofilm mass and the fungicidal effect of serum at concentrations ranging from 0.015 to 1 mg/l and from 0.015 to 512 mg/l for amphotericin B and echinocandins, respectively (P < .01–.05). Fluconazole exerted better antifungal activity in serum than traditionally biofilm-active antifungals against both examined biofilms. For fluconazole, significant differences were observed in susceptibility between serum-treated and serum-free biofilms at concentrations ranging from 0.015 to 8 mg/l and from 0.03 to 512 mg/l for C. albicans and C. parapsilosis isolates, respectively (P < .01–.05). The high antifungal activity of fluconazole in 50% serum both against C. albicans and C. parapsilosis biofilms supports the utility of fluconazole prophylaxis to reduce the risk of catheter-associated fungal infections." @default.
• W2896591601 created "2018-10-26" @default.
• W2896591601 creator A5018086631 @default.
• W2896591601 creator A5025608810 @default.
• W2896591601 creator A5042264262 @default.
• W2896591601 creator A5067103929 @default.
• W2896591601 creator A5071710951 @default.
• W2896591601 creator A5072336858 @default.
• W2896591601 creator A5091714274 @default.
• W2896591601 date "2018-10-18" @default.
• W2896591601 modified "2023-09-26" @default.
• W2896591601 title "Fluconazole is not inferior than caspofungin, micafungin or amphotericin B in the presence of 50% human serum against Candida albicans and Candida parapsilosis biofilms" @default.
• W2896591601 cites W1903085608 @default.
• W2896591601 cites W1904075288 @default.
• W2896591601 cites W1929090722 @default.
• W2896591601 cites W1948733660 @default.
• W2896591601 cites W1970856277 @default.
• W2896591601 cites W1973655697 @default.
• W2896591601 cites W1976499126 @default.
• W2896591601 cites W1991149656 @default.
• W2896591601 cites W2027091957 @default.
• W2896591601 cites W2032324661 @default.
• W2896591601 cites W2034599708 @default.
• W2896591601 cites W2038498116 @default.
• W2896591601 cites W2048732946 @default.
• W2896591601 cites W2053821655 @default.
• W2896591601 cites W2059892640 @default.
• W2896591601 cites W2064181237 @default.
• W2896591601 cites W2064712711 @default.
• W2896591601 cites W2082504072 @default.
• W2896591601 cites W2087712604 @default.
• W2896591601 cites W2114146849 @default.
• W2896591601 cites W2119587680 @default.
• W2896591601 cites W2120299440 @default.
• W2896591601 cites W2122695702 @default.
• W2896591601 cites W2147038977 @default.
• W2896591601 cites W2149491987 @default.
• W2896591601 cites W2172274380 @default.
• W2896591601 cites W2274626913 @default.
• W2896591601 cites W2343689319 @default.
• W2896591601 cites W2463601754 @default.
• W2896591601 cites W2593660254 @default.
• W2896591601 cites W2744549449 @default.
• W2896591601 cites W4253842255 @default.
• W2896591601 doi "https://doi.org/10.1093/mmy/myy108" @default.
• W2896591601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30339227" @default.
• W2896591601 hasPublicationYear "2018" @default.
• W2896591601 type Work @default.
• W2896591601 sameAs 2896591601 @default.
• W2896591601 citedByCount "6" @default.
• W2896591601 countsByYear W28965916012019 @default.
• W2896591601 countsByYear W28965916012020 @default.
• W2896591601 crossrefType "journal-article" @default.
• W2896591601 hasAuthorship W2896591601A5018086631 @default.
• W2896591601 hasAuthorship W2896591601A5025608810 @default.
• W2896591601 hasAuthorship W2896591601A5042264262 @default.
• W2896591601 hasAuthorship W2896591601A5067103929 @default.
• W2896591601 hasAuthorship W2896591601A5071710951 @default.
• W2896591601 hasAuthorship W2896591601A5072336858 @default.
• W2896591601 hasAuthorship W2896591601A5091714274 @default.
• W2896591601 hasConcept C145081991 @default.
• W2896591601 hasConcept C185592680 @default.
• W2896591601 hasConcept C2779020398 @default.
• W2896591601 hasConcept C2779443200 @default.
• W2896591601 hasConcept C2779548794 @default.
• W2896591601 hasConcept C2779629538 @default.
• W2896591601 hasConcept C2780402444 @default.
• W2896591601 hasConcept C2780651595 @default.
• W2896591601 hasConcept C2780917455 @default.
• W2896591601 hasConcept C2910751997 @default.
• W2896591601 hasConcept C523546767 @default.
• W2896591601 hasConcept C54355233 @default.
• W2896591601 hasConcept C58123911 @default.
• W2896591601 hasConcept C86803240 @default.
• W2896591601 hasConcept C89423630 @default.
• W2896591601 hasConcept C98274493 @default.
• W2896591601 hasConceptScore W2896591601C145081991 @default.
• W2896591601 hasConceptScore W2896591601C185592680 @default.
• W2896591601 hasConceptScore W2896591601C2779020398 @default.
• W2896591601 hasConceptScore W2896591601C2779443200 @default.
• W2896591601 hasConceptScore W2896591601C2779548794 @default.
• W2896591601 hasConceptScore W2896591601C2779629538 @default.
• W2896591601 hasConceptScore W2896591601C2780402444 @default.
• W2896591601 hasConceptScore W2896591601C2780651595 @default.
• W2896591601 hasConceptScore W2896591601C2780917455 @default.
• W2896591601 hasConceptScore W2896591601C2910751997 @default.
• W2896591601 hasConceptScore W2896591601C523546767 @default.
• W2896591601 hasConceptScore W2896591601C54355233 @default.
• W2896591601 hasConceptScore W2896591601C58123911 @default.
• W2896591601 hasConceptScore W2896591601C86803240 @default.
• W2896591601 hasConceptScore W2896591601C89423630 @default.
• W2896591601 hasConceptScore W2896591601C98274493 @default.
• W2896591601 hasIssue "5" @default.
• W2896591601 hasLocation W28965916011 @default.
• W2896591601 hasLocation W28965916012 @default.
• W2896591601 hasOpenAccess W2896591601 @default.
• W2896591601 hasPrimaryLocation W28965916011 @default.
• W2896591601 hasRelatedWork W1999751604 @default.

• next