FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896597443> ?p ?o ?g. }

• W2896597443 endingPage "7211" @default.
• W2896597443 startingPage "7205" @default.
• W2896597443 abstract "The miR-503 cluster is coordinately under-expressed in endometrial endometrioid adenocarcinoma and targets many oncogenes, cell cycle genes, DNA repair genes and chemotherapy response genes Eric J Devor,1,2 Elizabeth Cha,1 Akshaya Warrier,1 Marina D Miller,1 Jesus Gonzalez-Bosquet,1,2 Kimberly K Leslie1,2 1Department of Obstetrics and Gynecology, University of Iowa Carver College of Medicine, Iowa City, IA 52246, USA; 2Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, IA 52246, USA Background: The miR-503 miRNA cluster, located at Xq23.1, is composed of six miRNAs; miR-424, miR-503, miR-542, miR-450a-1, miR-450a-2 and miR-450b. Numerous studies have focused on the relationship of one or two members of the cluster and various human cancers. Here, we suggest that the entire cluster as a single coordinately expressed polycistron transcribed from a single promoter in endometrial endometrioid adenocarcinoma (EEA). Subjects and methods: A tissue panel composed of twenty histologically confirmed endometrial endometrioid adenocarcinomas (EEA) and four benign endometrium was assembled under informed consent. Expression of each member of the miR-503 cluster was determined by quantitative PCR and differences in expression between EEA and benign tissues were assessed via the standard ΔΔCt method. In addition, the role of promoter methylation status in miRNA expression was examined in Ishikawa H cells following exposure to the cytidine analog Decitabine. Results: Expression of each member of the miR-503 cluster is significantly down-regulated in EEA in our tumor sample. Both in our tumor sample and in The Cancer Genome Atlas (TCGA) there is evidence of highly correlated expression further supporting the idea that the miR-503 cluster is a polycistron. Looking at each member of the miR-503 cluster we were able to identify 55 unique experimentally validated target genes which include a substantial number of genes involved in carcinogenesis, DNA damage response, cell cycle regulation and chemotherapeutic response. We also found preliminary evidence that regulation of the miR-503 cluster is governed by methylation of the promoter in EEA. Conclusion: The totality of the data presented here strongly suggest that the miR-503 cluster as a whole merits further investigation as an important potential therapeutic target in EEA. Keywords: microRNA-503 cluster, polycistron, endometrial cancer, methylation, decitabine, TCGA, correlated expression" @default.
• W2896597443 created "2018-10-26" @default.
• W2896597443 creator A5010768926 @default.
• W2896597443 creator A5020590235 @default.
• W2896597443 creator A5033621036 @default.
• W2896597443 creator A5045245691 @default.
• W2896597443 creator A5046875012 @default.
• W2896597443 creator A5088155695 @default.
• W2896597443 date "2018-10-01" @default.
• W2896597443 modified "2023-10-17" @default.
• W2896597443 title "The miR-503 cluster is coordinately under-expressed in endometrial endometrioid adenocarcinoma and targets many oncogenes, cell cycle genes, DNA repair genes and chemotherapy response genes" @default.
• W2896597443 cites W1696199194 @default.
• W2896597443 cites W1895927552 @default.
• W2896597443 cites W1973242253 @default.
• W2896597443 cites W2000023414 @default.
• W2896597443 cites W2041440766 @default.
• W2896597443 cites W2043704189 @default.
• W2896597443 cites W2053036179 @default.
• W2896597443 cites W2072334795 @default.
• W2896597443 cites W2079085536 @default.
• W2896597443 cites W2082924833 @default.
• W2896597443 cites W2093977577 @default.
• W2896597443 cites W2107277218 @default.
• W2896597443 cites W2111467397 @default.
• W2896597443 cites W2114570899 @default.
• W2896597443 cites W2123059293 @default.
• W2896597443 cites W2148748188 @default.
• W2896597443 cites W2163316512 @default.
• W2896597443 cites W2169275131 @default.
• W2896597443 cites W2174734928 @default.
• W2896597443 cites W2192080449 @default.
• W2896597443 cites W2312857799 @default.
• W2896597443 cites W2397455608 @default.
• W2896597443 cites W2412522129 @default.
• W2896597443 cites W2417377450 @default.
• W2896597443 cites W2570259867 @default.
• W2896597443 cites W2603810908 @default.
• W2896597443 cites W2604531262 @default.
• W2896597443 cites W2612264004 @default.
• W2896597443 doi "https://doi.org/10.2147/ott.s180921" @default.
• W2896597443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6203085" @default.
• W2896597443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30425513" @default.
• W2896597443 hasPublicationYear "2018" @default.
• W2896597443 type Work @default.
• W2896597443 sameAs 2896597443 @default.
• W2896597443 citedByCount "8" @default.
• W2896597443 countsByYear W28965974432019 @default.
• W2896597443 countsByYear W28965974432021 @default.
• W2896597443 countsByYear W28965974432022 @default.
• W2896597443 countsByYear W28965974432023 @default.
• W2896597443 crossrefType "journal-article" @default.
• W2896597443 hasAuthorship W2896597443A5010768926 @default.
• W2896597443 hasAuthorship W2896597443A5020590235 @default.
• W2896597443 hasAuthorship W2896597443A5033621036 @default.
• W2896597443 hasAuthorship W2896597443A5045245691 @default.
• W2896597443 hasAuthorship W2896597443A5046875012 @default.
• W2896597443 hasAuthorship W2896597443A5088155695 @default.
• W2896597443 hasBestOaLocation W28965974431 @default.
• W2896597443 hasConcept C101762097 @default.
• W2896597443 hasConcept C104317684 @default.
• W2896597443 hasConcept C121608353 @default.
• W2896597443 hasConcept C143998085 @default.
• W2896597443 hasConcept C145059251 @default.
• W2896597443 hasConcept C150194340 @default.
• W2896597443 hasConcept C190727270 @default.
• W2896597443 hasConcept C2777088508 @default.
• W2896597443 hasConcept C2781182431 @default.
• W2896597443 hasConcept C502942594 @default.
• W2896597443 hasConcept C54355233 @default.
• W2896597443 hasConcept C71924100 @default.
• W2896597443 hasConcept C86803240 @default.
• W2896597443 hasConceptScore W2896597443C101762097 @default.
• W2896597443 hasConceptScore W2896597443C104317684 @default.
• W2896597443 hasConceptScore W2896597443C121608353 @default.
• W2896597443 hasConceptScore W2896597443C143998085 @default.
• W2896597443 hasConceptScore W2896597443C145059251 @default.
• W2896597443 hasConceptScore W2896597443C150194340 @default.
• W2896597443 hasConceptScore W2896597443C190727270 @default.
• W2896597443 hasConceptScore W2896597443C2777088508 @default.
• W2896597443 hasConceptScore W2896597443C2781182431 @default.
• W2896597443 hasConceptScore W2896597443C502942594 @default.
• W2896597443 hasConceptScore W2896597443C54355233 @default.
• W2896597443 hasConceptScore W2896597443C71924100 @default.
• W2896597443 hasConceptScore W2896597443C86803240 @default.
• W2896597443 hasLocation W28965974431 @default.
• W2896597443 hasLocation W28965974432 @default.
• W2896597443 hasLocation W28965974433 @default.
• W2896597443 hasLocation W28965974434 @default.
• W2896597443 hasOpenAccess W2896597443 @default.
• W2896597443 hasPrimaryLocation W28965974431 @default.
• W2896597443 hasRelatedWork W129398428 @default.
• W2896597443 hasRelatedWork W184057646 @default.
• W2896597443 hasRelatedWork W1967718992 @default.
• W2896597443 hasRelatedWork W1969771092 @default.
• W2896597443 hasRelatedWork W2007418658 @default.
• W2896597443 hasRelatedWork W2025529750 @default.
• W2896597443 hasRelatedWork W2042874675 @default.
• W2896597443 hasRelatedWork W2795723184 @default.

• next