Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896599178> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2896599178 abstract "Fraction lipophilicity index (FLI) was developed as a metric for assessing oral drug likeness of ionizable chemical entities, as a weighted combination of log P and log D according to equation: FLI = 2xlog P–log D. The dataset included basic and acidic oral drugs introduced worldwide from 1994-2013. Using MedChemDesigner for logP and logD calculations, a drug-like FLI range of 1-8 is defined, whereas ClogP leads to a broader FLI(C) range of 1-10. A comparison of FLI with Rule of 5 showed that oral drugs with a two fold violation were well accommodated within the specified FLI ranges. Calculations of FLI and FLI(C) for 41 drugs with poor/moderately absorption showed that 40% of them have values outside the suggested drug-like ranges, while a distinct gap in the FLI and FLI(C) space permits the recommendation of ‘safer' ranges: for bases between 5-8 and 5-10 for FLI and FLI(C), respectively, and for acids between 4-7. Application of FLI to a test set of investigational compounds placed all of them within the drug-like FLI/ FLI(C) range, while discriminating two out of three low permeable molecules." @default.
- W2896599178 created "2018-10-26" @default.
- W2896599178 creator A5024412447 @default.
- W2896599178 creator A5026499401 @default.
- W2896599178 creator A5072428548 @default.
- W2896599178 date "2019-01-01" @default.
- W2896599178 modified "2023-09-26" @default.
- W2896599178 title "Fraction Lipophilicity Index (FLI)" @default.
- W2896599178 cites W1498609695 @default.
- W2896599178 cites W1895993106 @default.
- W2896599178 cites W1966598577 @default.
- W2896599178 cites W1970062872 @default.
- W2896599178 cites W1981652993 @default.
- W2896599178 cites W1985785813 @default.
- W2896599178 cites W1995616574 @default.
- W2896599178 cites W1996100382 @default.
- W2896599178 cites W2003494512 @default.
- W2896599178 cites W2007001142 @default.
- W2896599178 cites W2008525757 @default.
- W2896599178 cites W2024674972 @default.
- W2896599178 cites W2025749008 @default.
- W2896599178 cites W2029363424 @default.
- W2896599178 cites W2039478311 @default.
- W2896599178 cites W2039620644 @default.
- W2896599178 cites W2044454707 @default.
- W2896599178 cites W2066663828 @default.
- W2896599178 cites W2070685035 @default.
- W2896599178 cites W2086106390 @default.
- W2896599178 cites W2105649494 @default.
- W2896599178 cites W2109349176 @default.
- W2896599178 cites W2127126040 @default.
- W2896599178 cites W2127790911 @default.
- W2896599178 cites W2141528038 @default.
- W2896599178 cites W2148103576 @default.
- W2896599178 cites W2157970175 @default.
- W2896599178 cites W2169303530 @default.
- W2896599178 cites W251393854 @default.
- W2896599178 cites W2672110751 @default.
- W2896599178 cites W4248107770 @default.
- W2896599178 cites W82186612 @default.
- W2896599178 doi "https://doi.org/10.4018/ijqspr.2019010104" @default.
- W2896599178 hasPublicationYear "2019" @default.
- W2896599178 type Work @default.
- W2896599178 sameAs 2896599178 @default.
- W2896599178 citedByCount "0" @default.
- W2896599178 crossrefType "journal-article" @default.
- W2896599178 hasAuthorship W2896599178A5024412447 @default.
- W2896599178 hasAuthorship W2896599178A5026499401 @default.
- W2896599178 hasAuthorship W2896599178A5072428548 @default.
- W2896599178 hasConcept C104317684 @default.
- W2896599178 hasConcept C185592680 @default.
- W2896599178 hasConcept C201399114 @default.
- W2896599178 hasConcept C2775905019 @default.
- W2896599178 hasConcept C2780035454 @default.
- W2896599178 hasConcept C33923547 @default.
- W2896599178 hasConcept C41847442 @default.
- W2896599178 hasConcept C55493867 @default.
- W2896599178 hasConcept C71240020 @default.
- W2896599178 hasConcept C71924100 @default.
- W2896599178 hasConcept C74187038 @default.
- W2896599178 hasConcept C98274493 @default.
- W2896599178 hasConcept C99726746 @default.
- W2896599178 hasConceptScore W2896599178C104317684 @default.
- W2896599178 hasConceptScore W2896599178C185592680 @default.
- W2896599178 hasConceptScore W2896599178C201399114 @default.
- W2896599178 hasConceptScore W2896599178C2775905019 @default.
- W2896599178 hasConceptScore W2896599178C2780035454 @default.
- W2896599178 hasConceptScore W2896599178C33923547 @default.
- W2896599178 hasConceptScore W2896599178C41847442 @default.
- W2896599178 hasConceptScore W2896599178C55493867 @default.
- W2896599178 hasConceptScore W2896599178C71240020 @default.
- W2896599178 hasConceptScore W2896599178C71924100 @default.
- W2896599178 hasConceptScore W2896599178C74187038 @default.
- W2896599178 hasConceptScore W2896599178C98274493 @default.
- W2896599178 hasConceptScore W2896599178C99726746 @default.
- W2896599178 hasLocation W28965991781 @default.
- W2896599178 hasOpenAccess W2896599178 @default.
- W2896599178 hasPrimaryLocation W28965991781 @default.
- W2896599178 hasRelatedWork W1983575384 @default.
- W2896599178 hasRelatedWork W1999608471 @default.
- W2896599178 hasRelatedWork W2044716063 @default.
- W2896599178 hasRelatedWork W2059891797 @default.
- W2896599178 hasRelatedWork W2077808686 @default.
- W2896599178 hasRelatedWork W2087831939 @default.
- W2896599178 hasRelatedWork W2380347753 @default.
- W2896599178 hasRelatedWork W2707449957 @default.
- W2896599178 hasRelatedWork W2896599178 @default.
- W2896599178 hasRelatedWork W4229801933 @default.
- W2896599178 isParatext "false" @default.
- W2896599178 isRetracted "false" @default.
- W2896599178 magId "2896599178" @default.
- W2896599178 workType "article" @default.