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• W2896600521 abstract "Bile salts (BSs) are important for the digestion and absorption of fats and fat-soluble vitamins in the small intestine. In this work, we scrutinized, with small-angle X-ray scattering (SAXS), the crucial functions of bile salts beyond their capacity for the interfacial stabilization of submicrometer-sized lipid particles. By studying a wide compositional range of BS-lipid dispersions using two widely applied lipids for drug-delivery systems (one a monoglyceride being stabilizer-sensitive and the other an aliphatic alcohol being relatively stabilizer-insensitive), we identified the necessary BS to lipid ratios to guarantee full emulsification. A novel ad hoc developed global small-angle-X-ray scattering analysis method revealed that the addition of BS hardly changes the bilayer thicknesses in bicontinuous phases, while significant membrane thinning is observed in the coexisting fluid lamellar phase. Furthermore, we show that a BS strongly decreases the average critical packing parameter. At increasing BS concentration, the order of phases formed is (i) the bicontinuous diamond cubic (Pn3m), (ii) the bicontinuous primitive cubic (Im3m), and (iii) the fluid lamellar phase (Lα). These distinctive findings on BS-driven “emulsification” and “membrane curvature reduction” provide new molecular-scale insights for the understanding of the interfacial action of bile salts on lipid assemblies." @default.
• W2896600521 created "2018-10-26" @default.
• W2896600521 creator A5014510323 @default.
• W2896600521 creator A5034361859 @default.
• W2896600521 creator A5073553170 @default.
• W2896600521 creator A5091217307 @default.
• W2896600521 date "2018-10-22" @default.
• W2896600521 modified "2023-09-24" @default.
• W2896600521 title "Bile Salts Caught in the Act: From Emulsification to Nanostructural Reorganization of Lipid Self-Assemblies" @default.
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• W2896600521 doi "https://doi.org/10.1021/acs.langmuir.8b02343" @default.
• W2896600521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30347980" @default.
• W2896600521 hasPublicationYear "2018" @default.
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