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- W2896603311 abstract "Abstract The aim of this study is to determine the significance of programmed death ligand 1 (PD‐L1 or CD274) methylation in relation to PD‐L1 expression and survival in melanoma. Despite the clinical importance of therapies targeting the PD‐1/PD‐L1 immune checkpoint in melanoma, factors regulating PD‐L1 expression, including epigenetic mechanisms, are not completely understood. In this study, we examined PD‐L1 promoter methylation in relation to PD‐L1 expression and overall survival in melanoma patients. Our results suggest that DNA methylation regulates PD‐L1 expression in melanoma, and we identify the key methylated CpG loci in the PD‐L1 promoter, establish PD‐L1 methylation as an independent survival prognostic factor, provide proof of concept for altering PD‐L1 expression by hypomethylating agents, and uncover that PD‐L1 methylation is associated with an interferon signaling transcriptional phenotype. Based on our findings, measuring and altering PD‐L1 promoter DNA methylation may have potential prognostic and therapeutic applications in melanoma." @default.
- W2896603311 created "2018-10-26" @default.
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- W2896603311 date "2018-11-22" @default.
- W2896603311 modified "2023-10-16" @default.
- W2896603311 title "PD‐L1 methylation regulates PD‐L1 expression and is associated with melanoma survival" @default.
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- W2896603311 doi "https://doi.org/10.1111/pcmr.12745" @default.
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