FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896606009> ?p ?o ?g. }

• W2896606009 abstract "Summary Genomes can vary within individual organisms. Programmed DNA elimination leads to dramatic changes in genome organisation during the germline–soma differentiation of ciliates 1 , lampreys 2 , nematodes 3,4 , and various other eukaryotes 5 . A particularly remarkable example of tissue-specific genome differentiation is the germline-restricted chromosome (GRC) in the zebra finch which is consistently absent from somatic cells 6 . Although the zebra finch is an important animal model system 7 , molecular evidence from its large GRC (>150 megabases) is limited to a short intergenic region 8 and a single mRNA 9 . Here, we combined cytogenetic, genomic, transcriptomic, and proteomic evidence to resolve the evolutionary origin and functional significance of the GRC. First, by generating tissue-specific de-novo linked-read genome assemblies and re-sequencing two additional germline and soma samples, we found that the GRC contains at least 115 genes which are paralogous to single-copy genes on 18 autosomes and the Z chromosome. We detected an amplification of ≥38 GRC-linked genes into high copy numbers (up to 308 copies) but, surprisingly, no enrichment of transposable elements on the GRC. Second, transcriptome and proteome data provided evidence for functional expression of GRC genes at the RNA and protein levels in testes and ovaries. Interestingly, the GRC is enriched for genes with highly expressed orthologs in chicken gonads and gene ontologies involved in female gonad development. Third, we detected evolutionary strata of GRC-linked genes. Developmental genes such as bicc1 and trim71 have resided on the GRC for tens of millions of years, whereas dozens have become GRC-linked very recently. The GRC is thus likely widespread in songbirds (half of all bird species) and its rapid evolution may have contributed to their diversification. Together, our results demonstrate a highly dynamic evolutionary history of the songbird GRC leading to dramatic germline–soma genome differences as a novel mechanism to minimise genetic conflict between germline and soma." @default.
• W2896606009 created "2018-10-26" @default.
• W2896606009 creator A5029225325 @default.
• W2896606009 creator A5032889201 @default.
• W2896606009 creator A5034479642 @default.
• W2896606009 creator A5038969481 @default.
• W2896606009 creator A5039533451 @default.
• W2896606009 creator A5056084728 @default.
• W2896606009 creator A5059227883 @default.
• W2896606009 creator A5065422217 @default.
• W2896606009 creator A5071742653 @default.
• W2896606009 creator A5072104523 @default.
• W2896606009 creator A5078683058 @default.
• W2896606009 creator A5086361625 @default.
• W2896606009 date "2018-10-16" @default.
• W2896606009 modified "2023-10-18" @default.
• W2896606009 title "Programmed DNA elimination of germline development genes in songbirds" @default.
• W2896606009 cites W1492174633 @default.
• W2896606009 cites W1544977403 @default.
• W2896606009 cites W1967390118 @default.
• W2896606009 cites W1968471467 @default.
• W2896606009 cites W1969669269 @default.
• W2896606009 cites W1993013993 @default.
• W2896606009 cites W2003415600 @default.
• W2896606009 cites W2007003847 @default.
• W2896606009 cites W2043790670 @default.
• W2896606009 cites W2077929344 @default.
• W2896606009 cites W2087939587 @default.
• W2896606009 cites W2109183032 @default.
• W2896606009 cites W2135416390 @default.
• W2896606009 cites W2136242244 @default.
• W2896606009 cites W2158405820 @default.
• W2896606009 cites W2175352995 @default.
• W2896606009 cites W2510851398 @default.
• W2896606009 cites W2564972022 @default.
• W2896606009 cites W2747962788 @default.
• W2896606009 cites W2767466964 @default.
• W2896606009 cites W2770429904 @default.
• W2896606009 cites W2785695887 @default.
• W2896606009 cites W2802347662 @default.
• W2896606009 cites W2804700167 @default.
• W2896606009 cites W2890011076 @default.
• W2896606009 cites W2950682063 @default.
• W2896606009 cites W2950897230 @default.
• W2896606009 cites W3021377459 @default.
• W2896606009 doi "https://doi.org/10.1101/444364" @default.
• W2896606009 hasPublicationYear "2018" @default.
• W2896606009 type Work @default.
• W2896606009 sameAs 2896606009 @default.
• W2896606009 citedByCount "5" @default.
• W2896606009 countsByYear W28966060092019 @default.
• W2896606009 countsByYear W28966060092020 @default.
• W2896606009 crossrefType "posted-content" @default.
• W2896606009 hasAuthorship W2896606009A5029225325 @default.
• W2896606009 hasAuthorship W2896606009A5032889201 @default.
• W2896606009 hasAuthorship W2896606009A5034479642 @default.
• W2896606009 hasAuthorship W2896606009A5038969481 @default.
• W2896606009 hasAuthorship W2896606009A5039533451 @default.
• W2896606009 hasAuthorship W2896606009A5056084728 @default.
• W2896606009 hasAuthorship W2896606009A5059227883 @default.
• W2896606009 hasAuthorship W2896606009A5065422217 @default.
• W2896606009 hasAuthorship W2896606009A5071742653 @default.
• W2896606009 hasAuthorship W2896606009A5072104523 @default.
• W2896606009 hasAuthorship W2896606009A5078683058 @default.
• W2896606009 hasAuthorship W2896606009A5086361625 @default.
• W2896606009 hasBestOaLocation W28966060091 @default.
• W2896606009 hasConcept C104317684 @default.
• W2896606009 hasConcept C109825262 @default.
• W2896606009 hasConcept C134305767 @default.
• W2896606009 hasConcept C141231307 @default.
• W2896606009 hasConcept C150194340 @default.
• W2896606009 hasConcept C162317418 @default.
• W2896606009 hasConcept C30481170 @default.
• W2896606009 hasConcept C54355233 @default.
• W2896606009 hasConcept C86803240 @default.
• W2896606009 hasConceptScore W2896606009C104317684 @default.
• W2896606009 hasConceptScore W2896606009C109825262 @default.
• W2896606009 hasConceptScore W2896606009C134305767 @default.
• W2896606009 hasConceptScore W2896606009C141231307 @default.
• W2896606009 hasConceptScore W2896606009C150194340 @default.
• W2896606009 hasConceptScore W2896606009C162317418 @default.
• W2896606009 hasConceptScore W2896606009C30481170 @default.
• W2896606009 hasConceptScore W2896606009C54355233 @default.
• W2896606009 hasConceptScore W2896606009C86803240 @default.
• W2896606009 hasLocation W28966060091 @default.
• W2896606009 hasLocation W28966060092 @default.
• W2896606009 hasLocation W28966060093 @default.
• W2896606009 hasLocation W28966060094 @default.
• W2896606009 hasLocation W28966060095 @default.
• W2896606009 hasLocation W28966060096 @default.
• W2896606009 hasOpenAccess W2896606009 @default.
• W2896606009 hasPrimaryLocation W28966060091 @default.
• W2896606009 hasRelatedWork W1817623438 @default.
• W2896606009 hasRelatedWork W1869002552 @default.
• W2896606009 hasRelatedWork W1930762737 @default.
• W2896606009 hasRelatedWork W1998119898 @default.
• W2896606009 hasRelatedWork W2031436818 @default.
• W2896606009 hasRelatedWork W2087438783 @default.
• W2896606009 hasRelatedWork W2113377893 @default.
• W2896606009 hasRelatedWork W2119103177 @default.

• next