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- W2896609871 abstract "Cytomegalovirus (CMV) is the most frequent congenital viral infection. Primary CMV-contact during pregnancy may lead to intrauterine infections which can cause severe CNS-damage to the fetus. Brain involvement is the major cause of disability in these fetuses. However, we are still lacking good in utero prognostic markers. White matter signal abnormalities have been described in a late gestational age of the fetus as markers of bad prognostic outcome. However, on prenatal MR images, white matter abnormalities may be under- or overestimated. This study aims to use spectroscopy in patients with CMV-infection and white matter abnormalities of the fetal brain in the third trimester. We present four cases (mean 32.5 gestational weeks) of CMV-infected fetuses. The intrauterine involvement was confirmed by amniotic fluid testing. All of the four cases presented with white matter abnormalities suspicious for CMV-involvement. Spectroscopy was done using a short echo time (31 ms). Spectroscopy findings were able to predict outcomes in the four cases, as confirmed by postnatal neurology and MRI-assessment. Fetuses with normal spectrum or mild myo-inositol increase presented normal development. On the other hand, high lactate was associated with postnatal abnormalities. MR-spectroscopy can be used for the assessment of the fetal brain in doubtful cases with maternal CMV-infection, particularly in late gestational age. It might be a helpful prognostic tool in the prediction of infectious brain involvement, especially in the presence of white matter abnormalities." @default.
- W2896609871 created "2018-10-26" @default.
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- W2896609871 date "2018-10-01" @default.
- W2896609871 modified "2023-10-18" @default.
- W2896609871 title "P11.08: MR-spectroscopy as a potential prognostic tool in the assessment of white matter abnormalities in cytomegalovirus infections" @default.
- W2896609871 doi "https://doi.org/10.1002/uog.19702" @default.
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