Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896611699> ?p ?o ?g. }
- W2896611699 endingPage "1108" @default.
- W2896611699 startingPage "1098" @default.
- W2896611699 abstract "Advances in diagnostic technology, including chronic intracranial EEG recordings, have confirmed the clinical observation of different temporal patterns of epileptic activity and seizure occurrence over a 24-h period. The rhythmic patterns in epileptic activity and seizure occurrence are probably related to vigilance states and circadian variation in excitatory and inhibitory balance. Core circadian genes BMAL1 and CLOCK, which code for transcription factors, have been shown to influence excitability and seizure threshold. Despite uncertainties about the relative contribution of vigilance states versus circadian rhythmicity, including circadian factors such as seizure timing improves sensitivity of seizure prediction algorithms in individual patients. Improved prediction of seizure occurrence opens the possibility for personalised antiepileptic drug-dosing regimens timed to particular phases of the circadian cycle to improve seizure control and to reduce side-effects and risks associated with seizures. Further studies are needed to clarify the pathways through which rhythmic patterns of epileptic activity are generated, because this might also inform future treatment options." @default.
- W2896611699 created "2018-10-26" @default.
- W2896611699 creator A5036565679 @default.
- W2896611699 creator A5046645524 @default.
- W2896611699 creator A5048803658 @default.
- W2896611699 creator A5051710863 @default.
- W2896611699 creator A5068124511 @default.
- W2896611699 creator A5082438380 @default.
- W2896611699 creator A5086684847 @default.
- W2896611699 date "2018-12-01" @default.
- W2896611699 modified "2023-10-13" @default.
- W2896611699 title "Circadian rhythm and epilepsy" @default.
- W2896611699 cites W1481483232 @default.
- W2896611699 cites W1537142000 @default.
- W2896611699 cites W1567514373 @default.
- W2896611699 cites W1604597881 @default.
- W2896611699 cites W1684892656 @default.
- W2896611699 cites W1754734214 @default.
- W2896611699 cites W1761975923 @default.
- W2896611699 cites W1805069909 @default.
- W2896611699 cites W1851489929 @default.
- W2896611699 cites W1885845753 @default.
- W2896611699 cites W1964615054 @default.
- W2896611699 cites W1967634043 @default.
- W2896611699 cites W1981082198 @default.
- W2896611699 cites W1992726958 @default.
- W2896611699 cites W1992832137 @default.
- W2896611699 cites W1998340140 @default.
- W2896611699 cites W2002293846 @default.
- W2896611699 cites W2007054480 @default.
- W2896611699 cites W2008966677 @default.
- W2896611699 cites W2010552891 @default.
- W2896611699 cites W2014461189 @default.
- W2896611699 cites W2043283885 @default.
- W2896611699 cites W2046710025 @default.
- W2896611699 cites W2051134160 @default.
- W2896611699 cites W2070555834 @default.
- W2896611699 cites W2072416063 @default.
- W2896611699 cites W2084429527 @default.
- W2896611699 cites W2086762859 @default.
- W2896611699 cites W2089170650 @default.
- W2896611699 cites W2099771167 @default.
- W2896611699 cites W2101254435 @default.
- W2896611699 cites W2105072886 @default.
- W2896611699 cites W2106496774 @default.
- W2896611699 cites W2119736042 @default.
- W2896611699 cites W2120745993 @default.
- W2896611699 cites W2120853742 @default.
- W2896611699 cites W2122858710 @default.
- W2896611699 cites W2123106689 @default.
- W2896611699 cites W2125286041 @default.
- W2896611699 cites W2131340219 @default.
- W2896611699 cites W2135837882 @default.
- W2896611699 cites W2136921993 @default.
- W2896611699 cites W2142382453 @default.
- W2896611699 cites W2143534230 @default.
- W2896611699 cites W2144813428 @default.
- W2896611699 cites W2146321872 @default.
- W2896611699 cites W2151929327 @default.
- W2896611699 cites W2171909972 @default.
- W2896611699 cites W2188421461 @default.
- W2896611699 cites W2236052756 @default.
- W2896611699 cites W2238779738 @default.
- W2896611699 cites W2302804942 @default.
- W2896611699 cites W2336384540 @default.
- W2896611699 cites W2336608069 @default.
- W2896611699 cites W2397377925 @default.
- W2896611699 cites W2409135931 @default.
- W2896611699 cites W2410851752 @default.
- W2896611699 cites W2468609052 @default.
- W2896611699 cites W2468803512 @default.
- W2896611699 cites W2472563750 @default.
- W2896611699 cites W2511912940 @default.
- W2896611699 cites W2516087592 @default.
- W2896611699 cites W2523699134 @default.
- W2896611699 cites W2593816418 @default.
- W2896611699 cites W2597356819 @default.
- W2896611699 cites W2617237563 @default.
- W2896611699 cites W2736062098 @default.
- W2896611699 cites W2738797743 @default.
- W2896611699 cites W2741800082 @default.
- W2896611699 cites W2762711294 @default.
- W2896611699 cites W2772152119 @default.
- W2896611699 cites W2772696292 @default.
- W2896611699 cites W2782520840 @default.
- W2896611699 cites W2786186674 @default.
- W2896611699 cites W2793028857 @default.
- W2896611699 cites W2799563305 @default.
- W2896611699 cites W296695699 @default.
- W2896611699 cites W3160121689 @default.
- W2896611699 cites W78542167 @default.
- W2896611699 doi "https://doi.org/10.1016/s1474-4422(18)30335-1" @default.
- W2896611699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30366868" @default.
- W2896611699 hasPublicationYear "2018" @default.
- W2896611699 type Work @default.
- W2896611699 sameAs 2896611699 @default.
- W2896611699 citedByCount "90" @default.
- W2896611699 countsByYear W28966116992019 @default.