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• W2896615780 abstract "Abstract The range of thermal tolerance is one of the main factors influencing the geographic distribution of species. Climate change projections predict increases in average and extreme temperatures over the coming decades; hence, the ability of living beings to resist these changes will depend on physiological and adaptive responses. On an evolutionary scale, changes will occur as the result of selective pressures on individual heritable differences. In this work, we studied the genetic basis of tolerance to high temperatures in the fly Drosophila melanogaster and whether this species presents sufficient genetic variability to allow expansion of its upper thermo‐tolerance limit. To do so, we used adult flies derived from a natural population belonging to the Drosophila Genetic Reference Panel, for which genomic sequencing data are available. We characterized the phenotypic variation of the upper thermal limit in 34 lines by measuring knockdown temperature (i.e., critical thermal maximum [ CT max]) by exposing flies to a ramp of increasing temperature (0.25°C/min). Fourteen percent of the variation in CT max is explained by the genetic variation across lines, without a significant sexual dimorphism. Through a genomewide association study, 12 single nucleotide polymorphisms associated with the CT max were identified. In most of these SNP s, the less frequent allele increased the upper thermal limit suggesting that this population harbors raw genetic variation capable of expanding its heat tolerance. This potential upper thermal tolerance increase has implications under the global warming scenario. Past climatic records show a very low incidence of days above CT max (10 days over 25 years); however, future climate scenarios predict 243 days with extreme high temperature above CT max from 2045 to 2070. Thus, in the context of the future climate warming, rising temperatures might drive the evolution of heat tolerance in this population by increasing the frequency of the alleles associated with higher CT max." @default.
• W2896615780 created "2018-10-26" @default.
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• W2896615780 date "2018-10-11" @default.
• W2896615780 modified "2023-10-14" @default.
• W2896615780 title "Genetic variation for tolerance to high temperatures in a population of<i>Drosophila melanogaster</i>" @default.
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• W2896615780 doi "https://doi.org/10.1002/ece3.4409" @default.
• W2896615780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6238130" @default.
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• W2896615780 hasPublicationYear "2018" @default.
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