FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896617712> ?p ?o ?g. }

• W2896617712 endingPage "120" @default.
• W2896617712 startingPage "109" @default.
• W2896617712 abstract "IL-1 family cytokines play a dual role in the gut, with different family members contributing either protective or pathogenic effects. IL-36γ is an IL-1 family cytokine involved in polarizing type-1 immune responses. However, its function in the gut, including in colorectal cancer pathogenesis, is not well appreciated. In a murine model of colon carcinoma, IL-36γ controls tertiary lymphoid structure formation and promotes a type-1 immune response concurrently with a decrease in expression of immune checkpoint molecules in the tumor microenvironment. Here, we demonstrate that IL-36γ plays a similar role in driving a pro-inflammatory phenotype in human colorectal cancer. We analyzed a cohort of 33 primary colorectal carcinoma tumors using imaging, flow cytometry, and transcriptomics to determine the pattern and role of IL-36γ expression in this disease. In the colorectal tumor microenvironment, we observed IL-36γ to be predominantly expressed by M1 macrophages and cells of the vasculature, including smooth muscle cells and high endothelial venules. This pattern of IL-36γ expression is associated with a CD4+ central memory T cell infiltrate and an increased density of B cells in tertiary lymphoid structures, as well as with markers of fibrosis. Conversely, expression of the antagonist to IL-36 signaling, IL-1F5, was associated with intratumoral expression of checkpoint molecules, including PD-1, PD-L1, and CTLA4, which can suppress the immune response. These data support a role for IL-36γ in the physiologic immune response to colorectal cancer by sustaining inflammation within the tumor microenvironment." @default.
• W2896617712 created "2018-10-26" @default.
• W2896617712 creator A5010029786 @default.
• W2896617712 creator A5015718270 @default.
• W2896617712 creator A5017259807 @default.
• W2896617712 creator A5026223504 @default.
• W2896617712 creator A5045047864 @default.
• W2896617712 creator A5054880022 @default.
• W2896617712 creator A5081199992 @default.
• W2896617712 creator A5082293320 @default.
• W2896617712 creator A5085554521 @default.
• W2896617712 creator A5087916609 @default.
• W2896617712 creator A5089759719 @default.
• W2896617712 date "2018-10-12" @default.
• W2896617712 modified "2023-10-16" @default.
• W2896617712 title "Association of IL-36γ with tertiary lymphoid structures and inflammatory immune infiltrates in human colorectal cancer" @default.
• W2896617712 cites W1562381130 @default.
• W2896617712 cites W1672050380 @default.
• W2896617712 cites W1831565360 @default.
• W2896617712 cites W1883422628 @default.
• W2896617712 cites W1907172463 @default.
• W2896617712 cites W1934094702 @default.
• W2896617712 cites W1965031244 @default.
• W2896617712 cites W1966389697 @default.
• W2896617712 cites W1970278160 @default.
• W2896617712 cites W1982910732 @default.
• W2896617712 cites W1988999016 @default.
• W2896617712 cites W1996065226 @default.
• W2896617712 cites W2009954324 @default.
• W2896617712 cites W2028141281 @default.
• W2896617712 cites W2046560134 @default.
• W2896617712 cites W2051771323 @default.
• W2896617712 cites W2062291274 @default.
• W2896617712 cites W2067591914 @default.
• W2896617712 cites W2099900951 @default.
• W2896617712 cites W2104906501 @default.
• W2896617712 cites W2110252240 @default.
• W2896617712 cites W2112382960 @default.
• W2896617712 cites W2113878188 @default.
• W2896617712 cites W2115420093 @default.
• W2896617712 cites W2123054674 @default.
• W2896617712 cites W2127898787 @default.
• W2896617712 cites W2134164289 @default.
• W2896617712 cites W2135491202 @default.
• W2896617712 cites W2139090710 @default.
• W2896617712 cites W2146303969 @default.
• W2896617712 cites W2154941270 @default.
• W2896617712 cites W2163544987 @default.
• W2896617712 cites W2170267675 @default.
• W2896617712 cites W2170423927 @default.
• W2896617712 cites W2229266281 @default.
• W2896617712 cites W2301044272 @default.
• W2896617712 cites W2302437989 @default.
• W2896617712 cites W2310046094 @default.
• W2896617712 cites W2339442385 @default.
• W2896617712 cites W2409430468 @default.
• W2896617712 cites W2411330539 @default.
• W2896617712 cites W2526165489 @default.
• W2896617712 cites W2533508881 @default.
• W2896617712 cites W2564058509 @default.
• W2896617712 cites W2589053981 @default.
• W2896617712 cites W2594373254 @default.
• W2896617712 cites W2604465118 @default.
• W2896617712 cites W2608885960 @default.
• W2896617712 cites W2746671904 @default.
• W2896617712 doi "https://doi.org/10.1007/s00262-018-2259-0" @default.
• W2896617712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7185158" @default.
• W2896617712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30315348" @default.
• W2896617712 hasPublicationYear "2018" @default.
• W2896617712 type Work @default.
• W2896617712 sameAs 2896617712 @default.
• W2896617712 citedByCount "58" @default.
• W2896617712 countsByYear W28966177122019 @default.
• W2896617712 countsByYear W28966177122020 @default.
• W2896617712 countsByYear W28966177122021 @default.
• W2896617712 countsByYear W28966177122022 @default.
• W2896617712 countsByYear W28966177122023 @default.
• W2896617712 crossrefType "journal-article" @default.
• W2896617712 hasAuthorship W2896617712A5010029786 @default.
• W2896617712 hasAuthorship W2896617712A5015718270 @default.
• W2896617712 hasAuthorship W2896617712A5017259807 @default.
• W2896617712 hasAuthorship W2896617712A5026223504 @default.
• W2896617712 hasAuthorship W2896617712A5045047864 @default.
• W2896617712 hasAuthorship W2896617712A5054880022 @default.
• W2896617712 hasAuthorship W2896617712A5081199992 @default.
• W2896617712 hasAuthorship W2896617712A5082293320 @default.
• W2896617712 hasAuthorship W2896617712A5085554521 @default.
• W2896617712 hasAuthorship W2896617712A5087916609 @default.
• W2896617712 hasAuthorship W2896617712A5089759719 @default.
• W2896617712 hasBestOaLocation W28966177122 @default.
• W2896617712 hasConcept C121608353 @default.
• W2896617712 hasConcept C126322002 @default.
• W2896617712 hasConcept C203014093 @default.
• W2896617712 hasConcept C2776090121 @default.
• W2896617712 hasConcept C2776107976 @default.
• W2896617712 hasConcept C2776914184 @default.
• W2896617712 hasConcept C2777701055 @default.
• W2896617712 hasConcept C2778690821 @default.

• next