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• W2896618046 abstract "Abstract Objective Autonomic nervous system is involved at the onset of Parkinson disease (PD), and alpha‐synuclein ( α ‐Syn) and its phosphorylated form (p‐ α Syn) have been detected in dermal autonomic nerve fibers of PD. We assessed disease specific conformation variant of α ‐Syn immunoreactivity in cutaneous nerves and characterized skin denervation patterns in PD and atypical parkinsonism (AP). Methods We enrolled 49 subjects, 19 with PD, 17 age‐matched healthy controls, and 13 with AP. The manifestations of disease were rated on clinical scales. Skin biopsies from ankle, thigh, and neck were analyzed by immunofluorescence for p‐ α Syn, 5G4 as a conformation specific antibody to pathogenic α ‐Syn and PGP9.5 as axonal marker. Intraepidermal nerve fiber density was measured in all anatomical sites as marker of neurodegeneration. Thirteen of the 19 PD underwent a 1 year follow‐up visit plus skin biopsies. Results PD subjects displayed more severe cervical skin denervation ( P < 0.03), which correlated to disease duration and worsened between initial and follow‐up examination ( P < 0.001). p‐ α Syn and 5G4 were equally sensitive and specific for the diagnosis of PD (area under the ROC was 0.839 for p‐ α Syn and 0.886 for 5G4). PD and AP with possible alpha‐synucleinopathies share the features of marked cervical denervation and the presence of 5G4. In contrast AP with possible tauopathies were normal. Interpretation Conformational specific forms of α ‐Syn are detectable in skin biopsy by immunofluorescence in PD, with a promising diagnostic efficiency similar to p‐ α Syn. Cervical cutaneous denervation correlates with disease duration and increases over time standing out as a potential biomarker of PD progression." @default.
• W2896618046 created "2018-10-26" @default.
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• W2896618046 date "2018-10-14" @default.
• W2896618046 modified "2023-10-18" @default.
• W2896618046 title "Cervical skin denervation associates with alpha‐synuclein aggregates in Parkinson disease" @default.
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• W2896618046 doi "https://doi.org/10.1002/acn3.669" @default.
• W2896618046 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6243385" @default.
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• W2896618046 hasPublicationYear "2018" @default.
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