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- W2896619216 abstract "Cathelicidin (Cath) is one of the antimicrobial peptides found in neutrophils and epithelial cells. The aim of this study was to identify the cells producing Cath-7 in goat mammary glands and to investigate the binding and neutralization abilities of goat Cath-7 against lipopolysaccharide (LPS). Mammary gland tissues and milk were collected 48 h after intramammary infusion with LPS and used for immunohistochemical determination of Cath-7 and measurement of Cath-7 concentrations and somatic cell counts (SCCs) in milk. Leukocytes were collected from milk and cultured to analyze the expression of Cath-7 mRNA and its concentration in the culture medium. Furthermore, Cath-7 was applied to LPS-coated microtiter plates to examine its ability to bind to LPS. The expression of selected cytokines in leukocytes cultured with Cath-7 was assessed by real-time polymerase chain reaction. We demonstrated that Cath-7 is localized in leukocytes present in the alveoli. Intramammary infusion with LPS increased the concentration of Cath-7 and SCCs in milk, and the expression of Cath-7 and its concentration in culture medium increased after leukocyte culture. We observed the binding of Cath-7 to LPS and found that Cath-7 decreased the expression of interleukin (IL)-6 in leukocytes cultured with LPS. These results indicate that Cath-7 is synthesized in leukocytes, is subsequently secreted into milk, and has the ability to bind to LPS, resulting in the suppression of IL-6 expression in leukocytes." @default.
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- W2896619216 date "2018-11-01" @default.
- W2896619216 modified "2023-10-05" @default.
- W2896619216 title "Investigation of the binding of goat cathelicidin-7 to lipopolysaccharide and leucocidal suppression of pro-inflammatory cytokines" @default.
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- W2896619216 doi "https://doi.org/10.1016/j.smallrumres.2018.10.006" @default.
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