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• W2896619466 abstract "Fear extinction does not prevent post-traumatic stress or have long-term therapeutic benefits in fear-related disorders unless extinction memories are easily retrieved at later encounters with the once-threatening stimulus. Previous research in rodents has pointed towards a role for spontaneous prefrontal activity occurring after extinction learning in stabilizing and consolidating extinction memories. In other memory domains spontaneous post-learning activity has been linked to dopamine. Here, we show that a neural activation pattern - evoked in the ventromedial prefrontal cortex (vmPFC) by the unexpected omission of the feared outcome during extinction learning - spontaneously reappears during postextinction rest. The number of spontaneous vmPFC pattern reactivations predicts extinction memory retrieval and vmPFC activation at test 24 h later. Critically, pharmacologically enhancing dopaminergic activity during extinction consolidation amplifies spontaneous vmPFC reactivations and correspondingly improves extinction memory retrieval at test. Hence, a spontaneous dopamine-dependent memory consolidation-based mechanism may underlie the long-term behavioral effects of fear extinction." @default.
• W2896619466 created "2018-10-26" @default.
• W2896619466 creator A5056291568 @default.
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• W2896619466 date "2018-10-16" @default.
• W2896619466 modified "2023-10-17" @default.
• W2896619466 title "Dopamine-dependent prefrontal reactivations explain long-term benefit of fear extinction" @default.
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• W2896619466 doi "https://doi.org/10.1038/s41467-018-06785-y" @default.
• W2896619466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191435" @default.
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• W2896619466 hasPublicationYear "2018" @default.
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