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• W2896620105 abstract "Schistosomes control inflammation in their hosts via highly effective mechanisms such as induction of Tregs, Bregs, and alternatively activated macrophages (AAMs). Notably, IPSE/alpha-1, the major secretory product from Schistosoma mansoni eggs, triggers basophils to release interleukin (IL)-4 and IL-13. Both cytokines are essential for AAM induction, suggesting an important role for IPSE/alpha-1 in inflammation control. Here, we show by in vitro co-culture experiments that IPSE/alpha-1-induced basophil IL-4/IL-13 inhibited pro-inflammatory cytokine release from human LPS-activated monocytes. This effect was cell/cell contact-independent but dependent on IL-4, since it was abrogated in the presence of anti-IL-4 antibodies. Importantly, the IPSE/alpha-1-induced IL-4/IL-13 release from basophils was amplified in the presence of LPS. Moreover, monocytes co-cultured in the presence of LPS with IPSE/alpha-1-stimulated basophils adopted an AAM-like phenotype as assessed by elevated expression of CD206 and CD209. The putative in vivo relevance of these findings was supported by immunohistological staining of S. mansoni-infected murine tissue revealing close physical contact between IPSE/alpha-1 and basophils in schistosome egg granulomas. Taken together, we found that IPSE/alpha-1 dampens inflammatory cytokine responses by triggering basophil IL-4/IL-13, in particular in the context of TLR activation, thereby turning inflammatory monocytes into anti-inflammatory AAMs. This might represent a mechanism used by schistosomes to control inflammation in the host." @default.
• W2896620105 created "2018-10-26" @default.
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• W2896620105 date "2018-10-10" @default.
• W2896620105 modified "2023-09-27" @default.
• W2896620105 title "Schistosoma mansoni Egg-Released IPSE/alpha-1 Dampens Inflammatory Cytokine Responses via Basophil Interleukin (IL)-4 and IL-13" @default.
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• W2896620105 cites W1823625017 @default.
• W2896620105 cites W1828023433 @default.
• W2896620105 cites W1897568757 @default.
• W2896620105 cites W1906468352 @default.
• W2896620105 cites W1964136853 @default.
• W2896620105 cites W1971790409 @default.
• W2896620105 cites W1972606545 @default.
• W2896620105 cites W1976341092 @default.
• W2896620105 cites W1985585453 @default.
• W2896620105 cites W1987958595 @default.
• W2896620105 cites W1988128973 @default.
• W2896620105 cites W1989142540 @default.
• W2896620105 cites W1991012007 @default.
• W2896620105 cites W1992768498 @default.
• W2896620105 cites W1998444876 @default.
• W2896620105 cites W2002726220 @default.
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• W2896620105 cites W2065210647 @default.
• W2896620105 cites W2067616322 @default.
• W2896620105 cites W2078557614 @default.
• W2896620105 cites W2085153098 @default.
• W2896620105 cites W2088065328 @default.
• W2896620105 cites W2088337800 @default.
• W2896620105 cites W2091790046 @default.
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• W2896620105 doi "https://doi.org/10.3389/fimmu.2018.02293" @default.
• W2896620105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191518" @default.
• W2896620105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30364177" @default.
• W2896620105 hasPublicationYear "2018" @default.
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