FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896625708> ?p ?o ?g. }

• W2896625708 endingPage "85" @default.
• W2896625708 startingPage "74" @default.
• W2896625708 abstract "In previous studies, we showed impaired DNA repair in human monocytes. Here, we addressed the question of whether human neutrophilic granulocytes that arise from the same precursor as monocytes exhibit a similar phenotype and are impaired in repairing their DNA. We show that neutrophilic granulocytes isolated from peripheral blood display a lack of the same repair proteins that are missing in monocytes and do not show repair of their DNA when damaged by ionising radiation (IR) or chemical ROS. Contrary to T cells, we observed no decline in the number of single-strand breaks following γ-radiation. Also, granulocytes did not show γH2AX foci formation while T cells and peripheral blood lymphocytes (PBL) responded. In comparison to PBL, XRCC1, PARP-1 and ligase III were not expressed and there was also no discernible signal for key damage response proteins ATM, ATR and DNA-PK_CS as well as γH2AX in neutrophils. Time course and dose-response experiments confirmed the absence of H2AX phosphorylation after radiation treatment although an accumulation of double-strand breaks was detected in the neutral Comet assay. Overall, the data indicate that terminally differentiated neutrophilic granulocytes in the peripheral blood display strong downregulation of DNA repair and DNA damage response factors, which should be taken into account if studies with whole peripheral blood containing granulocytes are performed, causing a significant intra-experimental variation in the cellular repair capacity." @default.
• W2896625708 created "2018-10-26" @default.
• W2896625708 creator A5026593378 @default.
• W2896625708 creator A5029955527 @default.
• W2896625708 creator A5046071983 @default.
• W2896625708 creator A5049425789 @default.
• W2896625708 creator A5063084823 @default.
• W2896625708 creator A5090124624 @default.
• W2896625708 date "2018-10-08" @default.
• W2896625708 modified "2023-09-26" @default.
• W2896625708 title "Compromised DNA Repair and Signalling in Human Granulocytes" @default.
• W2896625708 cites W1652069479 @default.
• W2896625708 cites W1976646654 @default.
• W2896625708 cites W1982465302 @default.
• W2896625708 cites W1984490069 @default.
• W2896625708 cites W2013301732 @default.
• W2896625708 cites W2018860370 @default.
• W2896625708 cites W2021215513 @default.
• W2896625708 cites W2027379868 @default.
• W2896625708 cites W2028392042 @default.
• W2896625708 cites W2032227357 @default.
• W2896625708 cites W2039092335 @default.
• W2896625708 cites W2049881915 @default.
• W2896625708 cites W2070322650 @default.
• W2896625708 cites W2085128107 @default.
• W2896625708 cites W2100197820 @default.
• W2896625708 cites W2108308472 @default.
• W2896625708 cites W2110817748 @default.
• W2896625708 cites W2111039071 @default.
• W2896625708 cites W2123414689 @default.
• W2896625708 cites W2134259738 @default.
• W2896625708 cites W2136558899 @default.
• W2896625708 cites W2141522272 @default.
• W2896625708 cites W2145019007 @default.
• W2896625708 cites W2157598200 @default.
• W2896625708 cites W2168851595 @default.
• W2896625708 cites W2177293095 @default.
• W2896625708 cites W2212776653 @default.
• W2896625708 cites W23135828 @default.
• W2896625708 cites W2332926761 @default.
• W2896625708 cites W2567582035 @default.
• W2896625708 cites W2571996518 @default.
• W2896625708 cites W2753229994 @default.
• W2896625708 cites W4292474425 @default.
• W2896625708 cites W2149128385 @default.
• W2896625708 doi "https://doi.org/10.1159/000492678" @default.
• W2896625708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6738182" @default.
• W2896625708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30296787" @default.
• W2896625708 hasPublicationYear "2018" @default.
• W2896625708 type Work @default.
• W2896625708 sameAs 2896625708 @default.
• W2896625708 citedByCount "10" @default.
• W2896625708 countsByYear W28966257082018 @default.
• W2896625708 countsByYear W28966257082020 @default.
• W2896625708 countsByYear W28966257082021 @default.
• W2896625708 countsByYear W28966257082022 @default.
• W2896625708 crossrefType "journal-article" @default.
• W2896625708 hasAuthorship W2896625708A5026593378 @default.
• W2896625708 hasAuthorship W2896625708A5029955527 @default.
• W2896625708 hasAuthorship W2896625708A5046071983 @default.
• W2896625708 hasAuthorship W2896625708A5049425789 @default.
• W2896625708 hasAuthorship W2896625708A5063084823 @default.
• W2896625708 hasAuthorship W2896625708A5090124624 @default.
• W2896625708 hasBestOaLocation W28966257081 @default.
• W2896625708 hasConcept C104317684 @default.
• W2896625708 hasConcept C134935766 @default.
• W2896625708 hasConcept C135763542 @default.
• W2896625708 hasConcept C143425029 @default.
• W2896625708 hasConcept C153209595 @default.
• W2896625708 hasConcept C153911025 @default.
• W2896625708 hasConcept C175114707 @default.
• W2896625708 hasConcept C203014093 @default.
• W2896625708 hasConcept C2776999993 @default.
• W2896625708 hasConcept C2777983669 @default.
• W2896625708 hasConcept C2780358455 @default.
• W2896625708 hasConcept C2781184567 @default.
• W2896625708 hasConcept C54355233 @default.
• W2896625708 hasConcept C552990157 @default.
• W2896625708 hasConcept C86803240 @default.
• W2896625708 hasConcept C95444343 @default.
• W2896625708 hasConceptScore W2896625708C104317684 @default.
• W2896625708 hasConceptScore W2896625708C134935766 @default.
• W2896625708 hasConceptScore W2896625708C135763542 @default.
• W2896625708 hasConceptScore W2896625708C143425029 @default.
• W2896625708 hasConceptScore W2896625708C153209595 @default.
• W2896625708 hasConceptScore W2896625708C153911025 @default.
• W2896625708 hasConceptScore W2896625708C175114707 @default.
• W2896625708 hasConceptScore W2896625708C203014093 @default.
• W2896625708 hasConceptScore W2896625708C2776999993 @default.
• W2896625708 hasConceptScore W2896625708C2777983669 @default.
• W2896625708 hasConceptScore W2896625708C2780358455 @default.
• W2896625708 hasConceptScore W2896625708C2781184567 @default.
• W2896625708 hasConceptScore W2896625708C54355233 @default.
• W2896625708 hasConceptScore W2896625708C552990157 @default.
• W2896625708 hasConceptScore W2896625708C86803240 @default.
• W2896625708 hasConceptScore W2896625708C95444343 @default.
• W2896625708 hasIssue "1" @default.
• W2896625708 hasLocation W28966257081 @default.

• next