FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2896628816> ?p ?o ?g. }

• W2896628816 abstract "The prevalence of dementia remains high and is predicted to rise as the population age distribution continues to shift to older ages. Interestingly, data from several large population-based epidemiological studies have at least demonstrated declining dementia incidence among more recent birth cohorts. This trend is thought to be related to a number of factors including increasing educational attainment and cognitive reserve, better cardiovascular risk factor control, and declining smoking habits. However, the relatively consistent cohort effect of declining dementia incidence rates has remained significant with adjustment for these and other exposure variables. We hypothesized a similar declining incidence rate would be observed in Western Pennsylvania in a pooled cohort sample and that part of this trend would be explained by education differences. We pooled data from two community-sampled prospective cohort studies with the same investigative team with similar study aims and sampling region: The Monongahela Valley Independent Elders Survey (MoVIES, 1987-2001) and The Monongahela-Youghiogheny Healthy Aging Team (MYHAT, 2006-Ongoing). Across both studies we identified four sufficiently sized decade-long birth cohorts spanning from 1902-1941. In an analysis sample of n=3010 participants (mean baseline age=75.7, 61% female, mean follow-up: 7.1 years), we identified 257 incident dementia cases diagnosed using the Clinical Dementia Rating. When compared to the most recent birth cohort (1932-1941), the oldest cohort (1902-1911) had a significantly higher incident dementia rate (HR=4.3, p<.001, 95% CI: 2.2 – 8.3) as did the second oldest cohort (1912-1921; HR=2.8, p=.001, 95% CI: 1.5 – 5.2). Analyses were adjusted for age, sex, and education. The cohort effect was consistent in sex-stratified analyses, with the additional finding that college educated women were less likely to develop dementia than women who did not finish high school (HR=.647, p=.039, 95% CI: .427 - .979). No education effect was observed in men. We observed a decline in incident dementia rates across subsequently younger birth cohorts independent of sex, education, and age. Further investigation remains to be done to examine factors influencing this well replicated trend, with education patterns likely playing a role." @default.
• W2896628816 created "2018-10-26" @default.
• W2896628816 creator A5000090216 @default.
• W2896628816 creator A5017835257 @default.
• W2896628816 creator A5021979900 @default.
• W2896628816 creator A5068056679 @default.
• W2896628816 creator A5081696204 @default.
• W2896628816 date "2018-07-01" @default.
• W2896628816 modified "2023-10-16" @default.
• W2896628816 title "P1‐623: DECLINING DEMENTIA INCIDENCE IN THE MONONGAHELA VALLEY: BIRTH COHORT ANALYSES FROM THE MOVIES AND MYHAT STUDIES" @default.
• W2896628816 doi "https://doi.org/10.1016/j.jalz.2018.06.636" @default.
• W2896628816 hasPublicationYear "2018" @default.
• W2896628816 type Work @default.
• W2896628816 sameAs 2896628816 @default.
• W2896628816 citedByCount "0" @default.
• W2896628816 crossrefType "journal-article" @default.
• W2896628816 hasAuthorship W2896628816A5000090216 @default.
• W2896628816 hasAuthorship W2896628816A5017835257 @default.
• W2896628816 hasAuthorship W2896628816A5021979900 @default.
• W2896628816 hasAuthorship W2896628816A5068056679 @default.
• W2896628816 hasAuthorship W2896628816A5081696204 @default.
• W2896628816 hasConcept C107130276 @default.
• W2896628816 hasConcept C120665830 @default.
• W2896628816 hasConcept C121332964 @default.
• W2896628816 hasConcept C126322002 @default.
• W2896628816 hasConcept C144024400 @default.
• W2896628816 hasConcept C149923435 @default.
• W2896628816 hasConcept C192091488 @default.
• W2896628816 hasConcept C201903717 @default.
• W2896628816 hasConcept C2779134260 @default.
• W2896628816 hasConcept C2779483572 @default.
• W2896628816 hasConcept C2908647359 @default.
• W2896628816 hasConcept C61511704 @default.
• W2896628816 hasConcept C71924100 @default.
• W2896628816 hasConcept C72563966 @default.
• W2896628816 hasConcept C74909509 @default.
• W2896628816 hasConcept C99454951 @default.
• W2896628816 hasConceptScore W2896628816C107130276 @default.
• W2896628816 hasConceptScore W2896628816C120665830 @default.
• W2896628816 hasConceptScore W2896628816C121332964 @default.
• W2896628816 hasConceptScore W2896628816C126322002 @default.
• W2896628816 hasConceptScore W2896628816C144024400 @default.
• W2896628816 hasConceptScore W2896628816C149923435 @default.
• W2896628816 hasConceptScore W2896628816C192091488 @default.
• W2896628816 hasConceptScore W2896628816C201903717 @default.
• W2896628816 hasConceptScore W2896628816C2779134260 @default.
• W2896628816 hasConceptScore W2896628816C2779483572 @default.
• W2896628816 hasConceptScore W2896628816C2908647359 @default.
• W2896628816 hasConceptScore W2896628816C61511704 @default.
• W2896628816 hasConceptScore W2896628816C71924100 @default.
• W2896628816 hasConceptScore W2896628816C72563966 @default.
• W2896628816 hasConceptScore W2896628816C74909509 @default.
• W2896628816 hasConceptScore W2896628816C99454951 @default.
• W2896628816 hasIssue "7S_Part_10" @default.
• W2896628816 hasLocation W28966288161 @default.
• W2896628816 hasOpenAccess W2896628816 @default.
• W2896628816 hasPrimaryLocation W28966288161 @default.
• W2896628816 hasRelatedWork W1999154515 @default.
• W2896628816 hasRelatedWork W2033706128 @default.
• W2896628816 hasRelatedWork W2039047228 @default.
• W2896628816 hasRelatedWork W2059358116 @default.
• W2896628816 hasRelatedWork W2109548539 @default.
• W2896628816 hasRelatedWork W2122992204 @default.
• W2896628816 hasRelatedWork W2160970628 @default.
• W2896628816 hasRelatedWork W2909258897 @default.
• W2896628816 hasRelatedWork W2910208221 @default.
• W2896628816 hasRelatedWork W3172893480 @default.
• W2896628816 hasVolume "14" @default.
• W2896628816 isParatext "false" @default.
• W2896628816 isRetracted "false" @default.
• W2896628816 magId "2896628816" @default.
• W2896628816 workType "article" @default.