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- W2896629663 abstract "Deficiency in neuronal acetyl choline and an increased acetyl cholinesterase (AChE) leading to dementia are the key features of Alzheimer's disease. Though numerous ache inhibitors are reported, most of them fail in vivo owing to the inability to cure disease and co-symptoms like aggression/hallucinations. Anthocyanins are reported to posess characteristic biological activities in vitro. Here we set out to study whether Anthocyanin and flavonoid cocktails (AFC) abrogate the LPS-induced biochemical and behavioral changes in mice and drosophila. Mice treated with anthocyanins cocktail (AFC, 25mg/kg/d, p.o., for 15d, n=5) were challenged with LPS (0.5mg/kg/d, ip, 5 days). Phenotypic manifestations were assessed by employing a battery of behavioral assays for dementia (elevated plus maze, Y-maze, Morris water maze, passive avoidance). Terminally, the hippocampi were biochemically assessed for mitochondrial dysfunction, oxidative stress and ache activity. Additionally adult drosophila treated with AFC (0.05% in diet, n=25, 6 replicates) were challenged with LPS (200μg, filter discs) and subjected to behavioral and biochemical tests. LPS exposure induced significant behavioral aberrations among mice evident from the mazes. The passive avoidance score was also found reduced among the LPS mice indicating severe dementia traits. AFC supplements attenuated the LPS-induced behavioral anomalies. Additionally AFC treatment reduced ache activity, oxidative stress (reduced malondialdehyde), and nitric oxide among LPS-mice. Further, mitochondrial membrane permeability was improved among AFC mice exposed to LPS. Among drosophila, LPS-induced general aggressive behavior, ache and oxidative markers were also abrogated by AFC supplements. Our data from mice and drosophila are suggestive of potent neuro-attenuatory propensity of anthocyanin and flavonoid cocktail against LPS-induced dementia in mice and drosophila however studies are warranted for long term implications." @default.
- W2896629663 created "2018-10-26" @default.
- W2896629663 creator A5009642161 @default.
- W2896629663 creator A5077522933 @default.
- W2896629663 date "2018-07-01" @default.
- W2896629663 modified "2023-10-16" @default.
- W2896629663 title "P2‐042: COCKTAIL OF FLAVONOIDS AND ANTHOCYANINS PROTECTS AGAINST DEMENTIA AND BIOCHEMICAL CHANGES IN A SCOPOLAMINE MODEL IN DROSOPHILA: AN EFFECIENT PRIMARY SCREEN FOR THERAPEUTICS" @default.
- W2896629663 doi "https://doi.org/10.1016/j.jalz.2018.06.726" @default.
- W2896629663 hasPublicationYear "2018" @default.
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